The effect of ropinirole on the quality of life in patients with restless legs syndrome in Korea: An 8-week, multicenter, prospective study

Yong Won Cho, Seung Bong Hong, Do Hyung Kim, Ho Won Lee, Eun Yeon Joo, Jee Hyun Kim, Won Chul Shin, Kee Hyung Park, Sun Jung Han, Hyang Woon Lee

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background and Purpose Dopamine agonists are first-line drugs for treating the symptoms of restless legs syndrome (RLS). However, few studies have investigated the effect of dopamine agonists on the quality of life (QoL) in RLS patients. We conducted a study to determine whether ropinirole exerts positive effects on the QoL in RLS patients and to analyze the under-lying factors. Methods Primary RLS patients from eight medical centers were recruited in the study. They were evaluated in the baseline phase using various questionnaires including the Korean versions of the International Restless Legs Scale (K-IRLS), RLS QoL questionnaire (K-RLSQoL), and the Short Form 36 Health Survey (SF-36). After taking ropinirole for 8 weeks the same questionnaires were again completed as a re-evaluation. We analyzed the statistical difference using a paired t-test, a Pearson's correlation, and a stepwise multiple regression in order to identify the factors associated with the QoL change. Results A total of 107 subjects, including 65 (60.7%) females, completed this study. They were aged 51.68±14.80 years (mean±SD) and had a symptom duration of 8.8±9.0 months. After treatment with ropinirole, there were significant improvements on the K-RLSQoL, SF-36, and K-IRLS. The Pearson's correlation analysis showed that the improvement of QoL in RLS patients was significantly correlated with the severity of RLS (r=0.236, p<0.014) at baseline. Conclusions The results from this study suggest that treatment with ropinirole can improve the QoL in RLS patients. The improvement in the QoL is more related with the improvement of RLS symptoms.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalJournal of Clinical Neurology (Korea)
Volume9
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Dopamine agonists
  • Quality of life
  • Restless legs syndrome
  • Sleep

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