TY - JOUR
T1 - The effect of probiotics, antibiotics, and antipyretic analgesics on gut microbiota modification
AU - Yun, Yeojun
AU - Kim, Han Na
AU - Kim, Song E.
AU - Chang, Yoosoo
AU - Ryu, Seungho
AU - Shin, Hocheol
AU - Woo, So Youn
AU - Kim, Hyung Lae
N1 - Funding Information:
This research was supported by the National Research Foundation of Korea (NRF), with funding by ICT & Future Planning (NRF-2014R1A2A2A04006291) and the Ministry of Education (NRF-2016R1A6A3A11932719). Additional support was received from the Intramural Research Support Program of Ewha Womans University School of Medicine and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), with funding by the Ministry of Health & Welfare (HI14C0072).
Publisher Copyright:
© 2017, Chonnam National University Medical School. All rights reserved.
PY - 2017/3
Y1 - 2017/3
N2 - Human gut microbial community is playing a critical role in human health and associated with different human disease. In parallel, probiotics, antibiotics, and antipyretic analgesics (AAs) were developed to improve human health or cure human diseases. We therefore examined how probiotics, antibiotics, and AAs influence to the gut microbiota. Three independent case/control studies were designed from the cross-sectional cohort data of 1,463 healthy Koreans. The composition of the gut microbiota in each case and control group was determined via 16S ribosomal RNA Illumina next-generation sequencing. The correlation between microbial taxa and the consumption of each drug was tested using zero-inflated Gaussian mixture models, with covariate adjustment of age, sex, and body mass index (BMI). Probiotics, antibiotics, and AAs consumption yielded the significant differences in the gut microbiota, represented the lower abundance of Megasphaera in probiotics, the higher abundance of Fusobacteria in antibiotics, and the higher abundance of Butyrivibrio and Verrucomicrobia in AAs, compared to each control group. The reduction of Erysipelotrichaceae family was common in three drugs consumption.
AB - Human gut microbial community is playing a critical role in human health and associated with different human disease. In parallel, probiotics, antibiotics, and antipyretic analgesics (AAs) were developed to improve human health or cure human diseases. We therefore examined how probiotics, antibiotics, and AAs influence to the gut microbiota. Three independent case/control studies were designed from the cross-sectional cohort data of 1,463 healthy Koreans. The composition of the gut microbiota in each case and control group was determined via 16S ribosomal RNA Illumina next-generation sequencing. The correlation between microbial taxa and the consumption of each drug was tested using zero-inflated Gaussian mixture models, with covariate adjustment of age, sex, and body mass index (BMI). Probiotics, antibiotics, and AAs consumption yielded the significant differences in the gut microbiota, represented the lower abundance of Megasphaera in probiotics, the higher abundance of Fusobacteria in antibiotics, and the higher abundance of Butyrivibrio and Verrucomicrobia in AAs, compared to each control group. The reduction of Erysipelotrichaceae family was common in three drugs consumption.
KW - Antibiotics
KW - Antipyretic analgesics
KW - Gut microbiota
KW - Probiotics
UR - http://www.scopus.com/inward/record.url?scp=85017541879&partnerID=8YFLogxK
U2 - 10.4167/jbv.2017.47.1.64
DO - 10.4167/jbv.2017.47.1.64
M3 - Article
AN - SCOPUS:85017541879
SN - 1598-2467
VL - 47
SP - 64
EP - 74
JO - Journal of Bacteriology and Virology
JF - Journal of Bacteriology and Virology
IS - 1
ER -