The effect of probiotics, antibiotics, and antipyretic analgesics on gut microbiota modification

Yeojun Yun, Han Na Kim, Song E. Kim, Yoosoo Chang, Seungho Ryu, Hocheol Shin, So Youn Woo, Hyung Lae Kim

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Human gut microbial community is playing a critical role in human health and associated with different human disease. In parallel, probiotics, antibiotics, and antipyretic analgesics (AAs) were developed to improve human health or cure human diseases. We therefore examined how probiotics, antibiotics, and AAs influence to the gut microbiota. Three independent case/control studies were designed from the cross-sectional cohort data of 1,463 healthy Koreans. The composition of the gut microbiota in each case and control group was determined via 16S ribosomal RNA Illumina next-generation sequencing. The correlation between microbial taxa and the consumption of each drug was tested using zero-inflated Gaussian mixture models, with covariate adjustment of age, sex, and body mass index (BMI). Probiotics, antibiotics, and AAs consumption yielded the significant differences in the gut microbiota, represented the lower abundance of Megasphaera in probiotics, the higher abundance of Fusobacteria in antibiotics, and the higher abundance of Butyrivibrio and Verrucomicrobia in AAs, compared to each control group. The reduction of Erysipelotrichaceae family was common in three drugs consumption.

Original languageEnglish
Pages (from-to)64-74
Number of pages11
JournalJournal of Bacteriology and Virology
Issue number1
StatePublished - Mar 2017

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF), with funding by ICT & Future Planning (NRF-2014R1A2A2A04006291) and the Ministry of Education (NRF-2016R1A6A3A11932719). Additional support was received from the Intramural Research Support Program of Ewha Womans University School of Medicine and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), with funding by the Ministry of Health & Welfare (HI14C0072).

Publisher Copyright:
© 2017, Chonnam National University Medical School. All rights reserved.


  • Antibiotics
  • Antipyretic analgesics
  • Gut microbiota
  • Probiotics


Dive into the research topics of 'The effect of probiotics, antibiotics, and antipyretic analgesics on gut microbiota modification'. Together they form a unique fingerprint.

Cite this