The purpose of this study was to evaluate whether Irradiated Allogenic Cancellous combined with tetracycline could be effective on new bone formation in a rat calvarial defect model. Twenty-seven male Harland Sprague- Dawley rats were assigned to one of three treatment groups; Irradiated Allogenic Cancellous Bone, Irradiated Allogenic Cancellous Bone/Tetra-cycline and non-graft control. This material was placed into 8mm calvarial critical sized defects (CSDs). They were measured histologically and radiographically following a 2, 4 and 8 weeks healing interval. One way ANOVA test was used to compare the difference between the control and graft group. In the histomorphometric analysis, new bone area of the Irradiated Allogenic Cancellous Bone group was greater than that in the Irradiated Allogenic Cancellous Bone/Tetracycline group at 4 and 8 weeks, but difference was not statistically significant (p>0.05). Within the limitation of the results of this study, it is suggested that irradiated Allogenic Cancellous Bone is effective graft material on bone formation in the rat calvarial defect model and tetracycline does not enhance bone regeneration when it is combined with Irradiated Allogenic Cancellous.
|Number of pages||6|
|Journal||Tissue Engineering and Regenerative Medicine|
|State||Published - Oct 2009|
- Critical size defect
- Irradiated allogenic cancellous bone
- Rat model