The effect of hydroxyproline and Pro-Hyp dipeptide on UV-damaged skin of hairless mice

Ji Hae Lee, Jeong Hye Seo, Young Ho Park, Wan Gi Kim, Kyung Min Lim, Sang Jun Lee

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Hydroxyproline and Pro-Hyp dipeptide are the digestive products of collagen hydrolysate called collagen peptide. Some suggested that collagen peptides could improve aged or damaged skins, however, the effects of collagen peptides on the skin have not been known. In this study, we investigated the effects of digestive products of collagen peptides, hydroxyproline and Pro-Hyp dipeptide on skin quality using the UV-damaged dorsal skin of hairless mouse as a model system. Female SKH hairless mice were pre-irradiated with UV for 7 weeks, and then hydroxyproline, Pro-Hyp dipeptide were orally administered for 7 weeks with UV irradiation. Wrinkle formation (by replica image), skin elasticity, barrier status (by TEWL, transepidermal water loss), epidermis thickness, and biophysical changes in the stratum corneum (by hematoxylin & eosin staining) were examined. With the oral peptide treatment, effects such as skin barrier maintenance, anti-skin thickening, and recovery of the stratum corneum were observed. These results indicate that oral intake of collagen peptides may have beneficial effects on damaged skin cells.

Original languageEnglish
Pages (from-to)436-442
Number of pages7
JournalKorean Journal of Food Science and Technology
Issue number4
StatePublished - 2008


  • Collagen peptide
  • Hydroxyproline
  • Photoaging
  • Pro-Hyp
  • Ultraviolet (UV)


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