The Effect of Dexmedetomidine on the Mini-Cog Score and High-Mobility Group Box 1 Levels in Elderly Patients with Postoperative Neurocognitive Disorders Undergoing Orthopedic Surgery

Seung Hee Yoo; Mi Jin Jue; Yu Hee Kim; Sooyoung Cho; Won Joong Kim; Kye Min Kim; Jong In Han; Heeseung Lee

doi:10.3390/jcm12206610

The Effect of Dexmedetomidine on the Mini-Cog Score and High-Mobility Group Box 1 Levels in Elderly Patients with Postoperative Neurocognitive Disorders Undergoing Orthopedic Surgery

Seung Hee Yoo
, Mi Jin Jue
, Yu Hee Kim
, Sooyoung Cho
, Won Joong Kim
, Kye Min Kim
, Jong In Han
, Heeseung Lee

Department of Anesthesia and Pain Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Dexmedetomidine prevents postoperative cognitive dysfunction by inhibiting high-mobility group box 1 (HMGB1), which acts as an inflammatory marker.

Original language	English
Article number	6610
Journal	Journal of Clinical Medicine
Volume	12
Issue number	20
DOIs	https://doi.org/10.3390/jcm12206610
State	Published - Oct 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

HMGB1
Mini-Cog
aged
dexmedetomidine
neurocognitive disorders
orthopedic surgery
postoperative cognitive complications

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10.3390/jcm12206610

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Yoo, S. H., Jue, M. J., Kim, Y. H., Cho, S., Kim, W. J., Kim, K. M., Han, J. I., & Lee, H. (2023). The Effect of Dexmedetomidine on the Mini-Cog Score and High-Mobility Group Box 1 Levels in Elderly Patients with Postoperative Neurocognitive Disorders Undergoing Orthopedic Surgery. Journal of Clinical Medicine, 12(20), Article 6610. https://doi.org/10.3390/jcm12206610

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title = "The Effect of Dexmedetomidine on the Mini-Cog Score and High-Mobility Group Box 1 Levels in Elderly Patients with Postoperative Neurocognitive Disorders Undergoing Orthopedic Surgery",

abstract = "Dexmedetomidine prevents postoperative cognitive dysfunction by inhibiting high-mobility group box 1 (HMGB1), which acts as an inflammatory marker.",

keywords = "HMGB1, Mini-Cog, aged, dexmedetomidine, neurocognitive disorders, orthopedic surgery, postoperative cognitive complications",

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doi = "10.3390/jcm12206610",

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AU - Jue, Mi Jin

AU - Kim, Yu Hee

AU - Cho, Sooyoung

AU - Kim, Won Joong

AU - Kim, Kye Min

AU - Han, Jong In

AU - Lee, Heeseung

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AB - Dexmedetomidine prevents postoperative cognitive dysfunction by inhibiting high-mobility group box 1 (HMGB1), which acts as an inflammatory marker.

KW - HMGB1

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KW - dexmedetomidine

KW - neurocognitive disorders

KW - orthopedic surgery

KW - postoperative cognitive complications

UR - https://www.scopus.com/pages/publications/85175371727

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DO - 10.3390/jcm12206610

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The Effect of Dexmedetomidine on the Mini-Cog Score and High-Mobility Group Box 1 Levels in Elderly Patients with Postoperative Neurocognitive Disorders Undergoing Orthopedic Surgery

Abstract

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Keywords

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