The Effect of Dexmedetomidine on the Mini-Cog Score and High-Mobility Group Box 1 Levels in Elderly Patients with Postoperative Neurocognitive Disorders Undergoing Orthopedic Surgery

Seung Hee Yoo, Mi Jin Jue, Yu Hee Kim, Sooyoung Cho, Won Joong Kim, Kye Min Kim, Jong In Han, Heeseung Lee

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Dexmedetomidine prevents postoperative cognitive dysfunction by inhibiting high-mobility group box 1 (HMGB1), which acts as an inflammatory marker.

Original languageEnglish
Article number6610
JournalJournal of Clinical Medicine
Volume12
Issue number20
DOIs
StatePublished - Oct 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

  • HMGB1
  • Mini-Cog
  • aged
  • dexmedetomidine
  • neurocognitive disorders
  • orthopedic surgery
  • postoperative cognitive complications

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