The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by Genome mining gives insight into pathway evolution

Alessandra S. Eustáquio; Sang Jip Nam; Kevin Penn; Anna Lechner; Micheal C. Wilson; William Fenical; Paul R. Jensen; Bradley S. Moore

doi:10.1002/cbic.201000564

The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by Genome mining gives insight into pathway evolution

Alessandra S. Eustáquio, Sang Jip Nam, Kevin Penn, Anna Lechner, Micheal C. Wilson, William Fenical, Paul R. Jensen, Bradley S. Moore

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Evolving biosynthesis: Genome mining of the marine bacterium "Salinispora pacifica" has led to the discovery of the new proteasome inhibitor, salinosporamide K. Analysis of its biosynthetic gene cluster revealed a loss of gene function in relation to the salinosporamide A biosynthetic locus of Salinispora tropica that accounts for the structural differences in the two natural products.

Original language	English
Pages (from-to)	61-64
Number of pages	4
Journal	ChemBioChem
Volume	12
Issue number	1
DOIs	https://doi.org/10.1002/cbic.201000564
State	Published - Jan 2011

Keywords

Biosynthesis
Genome mining
Marine bacteria
Proteasome inhibitors
Salinosporamides

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10.1002/cbic.201000564

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abstract = "Evolving biosynthesis: Genome mining of the marine bacterium {"}Salinispora pacifica{"} has led to the discovery of the new proteasome inhibitor, salinosporamide K. Analysis of its biosynthetic gene cluster revealed a loss of gene function in relation to the salinosporamide A biosynthetic locus of Salinispora tropica that accounts for the structural differences in the two natural products.",

keywords = "Biosynthesis, Genome mining, Marine bacteria, Proteasome inhibitors, Salinosporamides",

author = "Eust{\'a}quio, \{Alessandra S.\} and Nam, \{Sang Jip\} and Kevin Penn and Anna Lechner and Wilson, \{Micheal C.\} and William Fenical and Jensen, \{Paul R.\} and Moore, \{Bradley S.\}",

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AU - Eustáquio, Alessandra S.

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AU - Penn, Kevin

AU - Lechner, Anna

AU - Wilson, Micheal C.

AU - Fenical, William

AU - Jensen, Paul R.

AU - Moore, Bradley S.

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AB - Evolving biosynthesis: Genome mining of the marine bacterium "Salinispora pacifica" has led to the discovery of the new proteasome inhibitor, salinosporamide K. Analysis of its biosynthetic gene cluster revealed a loss of gene function in relation to the salinosporamide A biosynthetic locus of Salinispora tropica that accounts for the structural differences in the two natural products.

KW - Biosynthesis

KW - Genome mining

KW - Marine bacteria

KW - Proteasome inhibitors

KW - Salinosporamides

UR - https://www.scopus.com/pages/publications/78650691813

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DO - 10.1002/cbic.201000564

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The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by Genome mining gives insight into pathway evolution

Abstract

Keywords

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