The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by Genome mining gives insight into pathway evolution

Alessandra S. Eustáquio; Sang Jip Nam; Kevin Penn; Anna Lechner; Micheal C. Wilson; William Fenical; Paul R. Jensen; Bradley S. Moore

doi:10.1002/cbic.201000564

The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by Genome mining gives insight into pathway evolution

Alessandra S. Eustáquio
, Sang Jip Nam
, Kevin Penn
, Anna Lechner
, Micheal C. Wilson
, William Fenical
, Paul R. Jensen
, Bradley S. Moore

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Evolving biosynthesis: Genome mining of the marine bacterium "Salinispora pacifica" has led to the discovery of the new proteasome inhibitor, salinosporamide K. Analysis of its biosynthetic gene cluster revealed a loss of gene function in relation to the salinosporamide A biosynthetic locus of Salinispora tropica that accounts for the structural differences in the two natural products.

Original language	English
Pages (from-to)	61-64
Number of pages	4
Journal	ChemBioChem
Volume	12
Issue number	1
DOIs	https://doi.org/10.1002/cbic.201000564
State	Published - Jan 2011

Keywords

Biosynthesis
Genome mining
Marine bacteria
Proteasome inhibitors
Salinosporamides

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10.1002/cbic.201000564

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abstract = "Evolving biosynthesis: Genome mining of the marine bacterium {"}Salinispora pacifica{"} has led to the discovery of the new proteasome inhibitor, salinosporamide K. Analysis of its biosynthetic gene cluster revealed a loss of gene function in relation to the salinosporamide A biosynthetic locus of Salinispora tropica that accounts for the structural differences in the two natural products.",

keywords = "Biosynthesis, Genome mining, Marine bacteria, Proteasome inhibitors, Salinosporamides",

author = "Eust{\'a}quio, \{Alessandra S.\} and Nam, \{Sang Jip\} and Kevin Penn and Anna Lechner and Wilson, \{Micheal C.\} and William Fenical and Jensen, \{Paul R.\} and Moore, \{Bradley S.\}",

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AU - Eustáquio, Alessandra S.

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AU - Penn, Kevin

AU - Lechner, Anna

AU - Wilson, Micheal C.

AU - Fenical, William

AU - Jensen, Paul R.

AU - Moore, Bradley S.

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AB - Evolving biosynthesis: Genome mining of the marine bacterium "Salinispora pacifica" has led to the discovery of the new proteasome inhibitor, salinosporamide K. Analysis of its biosynthetic gene cluster revealed a loss of gene function in relation to the salinosporamide A biosynthetic locus of Salinispora tropica that accounts for the structural differences in the two natural products.

KW - Biosynthesis

KW - Genome mining

KW - Marine bacteria

KW - Proteasome inhibitors

KW - Salinosporamides

UR - https://www.scopus.com/pages/publications/78650691813

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The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by Genome mining gives insight into pathway evolution

Abstract

Keywords

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