The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by Genome mining gives insight into pathway evolution

Alessandra S. Eustáquio, Sang Jip Nam, Kevin Penn, Anna Lechner, Micheal C. Wilson, William Fenical, Paul R. Jensen, Bradley S. Moore

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Evolving biosynthesis: Genome mining of the marine bacterium "Salinispora pacifica" has led to the discovery of the new proteasome inhibitor, salinosporamide K. Analysis of its biosynthetic gene cluster revealed a loss of gene function in relation to the salinosporamide A biosynthetic locus of Salinispora tropica that accounts for the structural differences in the two natural products.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalChemBioChem
Volume12
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Biosynthesis
  • Genome mining
  • Marine bacteria
  • Proteasome inhibitors
  • Salinosporamides

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