Abstract
A new monoterpenoid, neoroseoside (1), along with two previously reported compounds, 2″-O-α-L-rhamnosyl-6-C-fucosylluteolin (2) and farobin A (3) were isolated from the Zea mays. The structure of compound 1 was determined through the analysis spectroscopic data, including mass spectrometry (MS), infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR) data. The absolute configurations of 1 were deduced from the comparing the values of optical rotations and from the interpretation of electronic circular dichroism (ECD) spectra. Compounds 2 and 3 displayed moderate antibacterial activity against Streptococcus mutans ATCC 25175 (inhibition rates 24 % and 28 %, respectively) and Streptococcus sobrinus ATCC 33478 (inhibition rate of 26 %), at a concentration of 100 μg/mL, whereas compound 1 did not have any significant antibacterial activities. The compounds 1–3 also showed anti-inflammatory activity on cytokine IL-6 and TNF-α.
Original language | English |
---|---|
Article number | 129737 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 105 |
DOIs | |
State | Published - 1 Jun 2024 |
Bibliographical note
Publisher Copyright:© 2024 Elsevier Ltd
Keywords
- Anti-inflammatory
- ECD spectra
- Monoterpenoid
- Optical rotation
- Zea mays