The disassembly of a core-satellite nanoassembled substrate for colorimetric biomolecular detection

J. R. Waldeisen, T. Wang, B. M. Ross, L. P. Lee

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We present the fabrication of gold nanoassemblies constructed on a two-dimensional substrate, demonstrate colorimetric biomolecular sensing functionality via protease-mediate disassembly, and systematically analyze the "naked eye" detection properties by calculating a figure of merit. Optimization of the scattering spectra of the core-satellite nanoassemblies maximizes the signal-to-noise ratio during biosensing and enables the large colorimetric shift of this assay from orange (>630 nm) to green (∼560 nm) via the observation of scattered light in dark field (DF). Nanoconstructs with 50 nm cores and 30 nm or 50 nm satellites were found to be ideal for colorimetric readout.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages1442-1444
Number of pages3
StatePublished - 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 3 Oct 20107 Oct 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume3

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Country/TerritoryNetherlands
CityGroningen
Period3/10/107/10/10

Keywords

  • Biosensor
  • Colorimetric
  • Nanoassembly
  • Nanoparticle
  • Plasmonic

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