The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver

Ying Zhang, Jiyoung Park, Seong Jeong Han, Iha Park, Thang Nguyen Huu, Jong Suk Kim, Hyun Ae Woo, Seung Rock Lee

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Hepatic steatosis and subsequent fatty liver disease are developed in response to alcohol consumption. Reactive oxygen species (ROS) are thought to play an important role in the alcoholic fatty liver disease (AFLD). However, the molecular targets of ROS and the underlying cellular mechanisms are unknown. Here, we investigate roles of peroxiredoxin III and redox regulation of phosphatase and tension homolog deleted on chromosome 10 (PTEN) in the alcoholic fatty liver. Alcohol-induced mitochondrial oxidative stress was found to contribute to reversible oxidation of PTEN, which results in Akt and MAPK hyperactivation with elevated levels of the lipogenesis regulators SREBP1c and PPARγ. Moreover, mitochondrial peroxiredoxin III was found to have antagonistic effects on lipogenesis via the redox regulation of PTEN by removing ROS, upon alcohol exposure. This study demonstrated that redox regulation of PTEN and peroxiredoxin III play crucial roles in the development of AFLD.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalFree Radical Biology and Medicine
Volume162
DOIs
StatePublished - Jan 2021

Keywords

  • Alcohol
  • Alcoholic fatty liver disease
  • Hepatic steatosis
  • Peroxiredoxin III
  • PTEN
  • Reactive oxygen species

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