The convenient synthesis and evaluation of the anticancer activities of new resveratrol derivatives

Hyung In Moon, Ill Min Chung, Jae Chul Jung, Eunyoung Lim, Yongnam Lee, Seikwan Oh, Mankil Jung

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In the present study we report the simple synthesis and antitumour activity of novel stilbene derivatives 1322. The key synthetic strategies involved Wadsworth-Horner-Emmons condensation and coupling reactions in high yields. All compounds showed significant growth inhibition on human tumour cell lines, with the most potent compound (19) exhibiting an IC50 of 5.7 μM 11.4 μM in vitro.

Original languageEnglish
Pages (from-to)328-336
Number of pages9
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume24
Issue number2
DOIs
StatePublished - Apr 2009

Bibliographical note

Funding Information:
This work has been supported by a KOSEF Brain Neurobiology Grant (2007), Ewha Global Challenge (BK21) grant, a research grant from the Ministry of Health & Welfare (Project No B040002), the Republic of Korea, E. L and Y. L the fellowship of the BK 21 program from the Ministry of Education and Human Resources Development and the Seoul Science Fellowship Program, and a grant (20070301-034-026-007-04-00) from BioGreen 21 Program, Rural Development Administration, Republic of Korea. Hyung-In Moon and Ill-Min Chung equally contributed to this work.

Keywords

  • Anticancer activity
  • Stilbene derivatives
  • Wadsworth-Horner-Emmons reaction

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