The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection

Seul Ki Choi, Gil Im Mun, Eun Choi, Seo Young Kim, Youngjoo Kwon, Younghwa Na, Yun Sil Lee

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation.

Original languageEnglish
Pages (from-to)2379-2383
Number of pages5
JournalJournal of Natural Products
Volume80
Issue number8
DOIs
StatePublished - 25 Aug 2017

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