Abstract
Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation.
Original language | English |
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Pages (from-to) | 2379-2383 |
Number of pages | 5 |
Journal | Journal of Natural Products |
Volume | 80 |
Issue number | 8 |
DOIs | |
State | Published - 25 Aug 2017 |
Bibliographical note
Publisher Copyright:© 2017 The American Chemical Society and American Society of Pharmacognosy.