The changes in the expressions of γ-aminobutyric acid transporters in the gerbil hippocampal complex following spontaneous seizure

Tae Cheon Kang; Hyun Sook Kim; Myung Oak Seo; Seung Kook Park; Hyeok Yil Kwon; Jung Hoon Kang; Moo Ho Won

doi:10.1016/S0304-3940(01)02088-2

The changes in the expressions of γ-aminobutyric acid transporters in the gerbil hippocampal complex following spontaneous seizure

Tae Cheon Kang, Hyun Sook Kim, Myung Oak Seo, Seung Kook Park, Hyeok Yil Kwon, Jung Hoon Kang, Moo Ho Won

Department of Life Science

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

To identify the roles of γ-aminobutyric acid (GABA) transporter in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of GABA transporters (GAT) expression was conducted. GAT-1 immunoreactivity was more strongly detected in the pre-seizure group of seizure sensitive (SS) gerbils than that seen in the seizure resistant group. 30 min postictal, the density of GAT-1 immunoreactivity was significantly decreased in the hippocampal complex, as compared to pre-seizure group. 12 h after seizure on-set, the GAT immunodensity recovered to the pre-seizure level. Following the onset of seizure, GAT-3 immunoreactivity remained unchanged. These results suggest that the increase of GAT-1 expression in the SS gerbil hippocampus may affect epileptogenesis in this animal, and the alteration of immunoreactivity following seizure may be compensatory responses to modulate seizure activity.

Original language	English
Pages (from-to)	29-32
Number of pages	4
Journal	Neuroscience Letters
Volume	310
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(01)02088-2
State	Published - 7 Sep 2001

Bibliographical note

Funding Information:
The authors would like to thank Mr Suek Han and Kyung Jin Lee for their technical helps on the illustrations. This work was supported by grant No.2000-1-21300-001-2 from the Basic Research Program of the Korea Science & Engineering Foundation.

Keywords

γ-aminobutyric acid transporter
Epileptogenesis
Gerbil
Hippocampus
Seizure

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10.1016/S0304-3940(01)02088-2

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title = "The changes in the expressions of γ-aminobutyric acid transporters in the gerbil hippocampal complex following spontaneous seizure",

abstract = "To identify the roles of γ-aminobutyric acid (GABA) transporter in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of GABA transporters (GAT) expression was conducted. GAT-1 immunoreactivity was more strongly detected in the pre-seizure group of seizure sensitive (SS) gerbils than that seen in the seizure resistant group. 30 min postictal, the density of GAT-1 immunoreactivity was significantly decreased in the hippocampal complex, as compared to pre-seizure group. 12 h after seizure on-set, the GAT immunodensity recovered to the pre-seizure level. Following the onset of seizure, GAT-3 immunoreactivity remained unchanged. These results suggest that the increase of GAT-1 expression in the SS gerbil hippocampus may affect epileptogenesis in this animal, and the alteration of immunoreactivity following seizure may be compensatory responses to modulate seizure activity.",

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author = "Kang, {Tae Cheon} and Kim, {Hyun Sook} and Seo, {Myung Oak} and Park, {Seung Kook} and Kwon, {Hyeok Yil} and Kang, {Jung Hoon} and Won, {Moo Ho}",

note = "Funding Information: The authors would like to thank Mr Suek Han and Kyung Jin Lee for their technical helps on the illustrations. This work was supported by grant No.2000-1-21300-001-2 from the Basic Research Program of the Korea Science & Engineering Foundation.",

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AU - Park, Seung Kook

AU - Kwon, Hyeok Yil

AU - Kang, Jung Hoon

AU - Won, Moo Ho

N1 - Funding Information: The authors would like to thank Mr Suek Han and Kyung Jin Lee for their technical helps on the illustrations. This work was supported by grant No.2000-1-21300-001-2 from the Basic Research Program of the Korea Science & Engineering Foundation.

PY - 2001/9/7

Y1 - 2001/9/7

N2 - To identify the roles of γ-aminobutyric acid (GABA) transporter in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of GABA transporters (GAT) expression was conducted. GAT-1 immunoreactivity was more strongly detected in the pre-seizure group of seizure sensitive (SS) gerbils than that seen in the seizure resistant group. 30 min postictal, the density of GAT-1 immunoreactivity was significantly decreased in the hippocampal complex, as compared to pre-seizure group. 12 h after seizure on-set, the GAT immunodensity recovered to the pre-seizure level. Following the onset of seizure, GAT-3 immunoreactivity remained unchanged. These results suggest that the increase of GAT-1 expression in the SS gerbil hippocampus may affect epileptogenesis in this animal, and the alteration of immunoreactivity following seizure may be compensatory responses to modulate seizure activity.

AB - To identify the roles of γ-aminobutyric acid (GABA) transporter in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of GABA transporters (GAT) expression was conducted. GAT-1 immunoreactivity was more strongly detected in the pre-seizure group of seizure sensitive (SS) gerbils than that seen in the seizure resistant group. 30 min postictal, the density of GAT-1 immunoreactivity was significantly decreased in the hippocampal complex, as compared to pre-seizure group. 12 h after seizure on-set, the GAT immunodensity recovered to the pre-seizure level. Following the onset of seizure, GAT-3 immunoreactivity remained unchanged. These results suggest that the increase of GAT-1 expression in the SS gerbil hippocampus may affect epileptogenesis in this animal, and the alteration of immunoreactivity following seizure may be compensatory responses to modulate seizure activity.

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The changes in the expressions of γ-aminobutyric acid transporters in the gerbil hippocampal complex following spontaneous seizure

Abstract

Bibliographical note

Keywords

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