The changes in the expressions of γ-aminobutyric acid transporters in the gerbil hippocampal complex following spontaneous seizure

Tae Cheon Kang, Hyun Sook Kim, Myung Oak Seo, Seung Kook Park, Hyeok Yil Kwon, Jung Hoon Kang, Moo Ho Won

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

To identify the roles of γ-aminobutyric acid (GABA) transporter in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of GABA transporters (GAT) expression was conducted. GAT-1 immunoreactivity was more strongly detected in the pre-seizure group of seizure sensitive (SS) gerbils than that seen in the seizure resistant group. 30 min postictal, the density of GAT-1 immunoreactivity was significantly decreased in the hippocampal complex, as compared to pre-seizure group. 12 h after seizure on-set, the GAT immunodensity recovered to the pre-seizure level. Following the onset of seizure, GAT-3 immunoreactivity remained unchanged. These results suggest that the increase of GAT-1 expression in the SS gerbil hippocampus may affect epileptogenesis in this animal, and the alteration of immunoreactivity following seizure may be compensatory responses to modulate seizure activity.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalNeuroscience Letters
Volume310
Issue number1
DOIs
StatePublished - 7 Sep 2001

Keywords

  • γ-aminobutyric acid transporter
  • Epileptogenesis
  • Gerbil
  • Hippocampus
  • Seizure

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