Abstract
The birthdates of GABAergic amacrine cells in the rat retina were investigated by immunocytochemistry using anti-GABA and anti-bromodeoxyuridine (BrdU) antisera. The ratio of co-localization of GABA to BrdU increased gradually from embryonic-day 13 (E13) and showed a peak value on E18 in the central retina and on E20 in the periphery. After birth, until postnatal-day 3 (P3), a few co-localized cells were observed in the inner nuclear layer (INL). However, in the peripheral retina, co-localized cells were observed in the INL and ganglion cell layer until P5. Our results suggest that the birthdates of GABA-immunoreactive cells vary, depending on cell-type and that there is a temporal lag in the GABA-immunoreactive cell production in the peripheral retina relative to the central retina.
Original language | English |
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Pages (from-to) | 309-314 |
Number of pages | 6 |
Journal | Experimental Brain Research |
Volume | 128 |
Issue number | 3 |
DOIs | |
State | Published - 1999 |
Keywords
- Bromodeoxyuridine
- GABA
- Immunohistochemistry
- Proliferation
- Rat
- Retina