The Autophagy Regulator p62 Controls PTEN-Dependent Ciliogenesis

Hyowon Mun, Eun Ji Lee, Minah Park, Goo Taeg Oh, Jong Hoon Park

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Autophagy is a catabolic process required for maintaining intracellular energy homeostasis. It eliminates harmful proteins and recycles functional macromolecules back into the cell via cargo breakdown. Autophagy is generally suppressed under fed conditions and induced by serum starvation; therefore, it is considered to be a nutrient-sensing mechanism. Cilia, finger-like organelles harboring multiple receptors along their surface, are energy-sensing structures that are also triggered by serum deprivation. Herein, we verified the effect of autophagy alterations on cilia assembly and the specific underlying mechanisms. Autophagy flux altered either by drugs or autophagy-targeting siRNAs strongly inhibited ciliogenesis, and this inhibition was affected by p62, an autophagy regulator, via Pten/Dvl2/AurKA signaling.

Original languageEnglish
Article number465
JournalFrontiers in Cell and Developmental Biology
Volume8
DOIs
StatePublished - 10 Jun 2020

Bibliographical note

Funding Information:
Funding. This work was supported by grants from the Bio & Medical Technology Development Program (2015M3A9B6027555) and the Basic Science Program (2016R1A5A1011974 and 2019R1A2B5B03069738).

Publisher Copyright:
© Copyright © 2020 Mun, Lee, Park, Oh and Park.

Keywords

  • PTEN
  • SQSTM1/p62
  • autophagy
  • cilia
  • ciliogenesis

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