The association of pancreatic cancer incidence with smoking status and smoking amount in Korean men

Do Jin Nam, Chang Mo Oh, Eunhee Ha, Min Ho Kim, Eun Hye Yang, Hyo Choon Lee, Soon Su Shin, Woo Yeon Hwang, Ann Hee You, Jae Hong Ryoo

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


OBJECTIVES: Our study examined the dose-response relationship between smoking amounts (pack-years) and the risk of developing pancreatic cancer in Korean men. METHODS: Of 125,743 participants who underwent medical health checkups in 2009, 121,408 were included in the final analysis and observed for the development of pancreatic cancer. We evaluated the associations between smoking amounts and incident pancreatic cancer in 4 groups classified by pack-year amounts. Cox proportional hazards models were used to estimate the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of incident pancreatic cancer by comparing groups 2 (< 20 pack-year smokers), 3 (20- ≤ 40 pack-year smokers), and 4 (> 40 pack-year smokers) with group 1 (never smokers). RESULTS: During 527,974.5 person-years of follow-up, 245 incident cases of pancreatic cancer developed between 2009 and 2013. The multivariate-adjusted HRs (95% CIs) for incident pancreatic cancer in groups 2, 3, and 4 were 1.05 (0.76 to 1.45), 1.28 (0.91 to 1.80), and 1.57 (1.00 to 2.46), respectively (p for trend = 0.025). The HR (95% CI) of former smokers showed a dose-response relationship in the unadjusted model, but did not show a statistically significant association in the multivariate-adjusted model. The HR (95% CI) of current smokers showed a dose-response relationship in both the unadjusted (p for trend = 0.020) and multivariate-adjusted models (p for trend = 0.050). CONCLUSIONS: The risk of developing pancreatic cancer was higher in current smokers status than in former smokers among Korean men, indicating that smoking cessation may have a protective effect.

Original languageEnglish
Article numbere2022040
JournalEpidemiology and health
StatePublished - 2022

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea in 2020 (grant No. 2020R1G1A1102257).

Publisher Copyright:
© 2022, Korean Society of Epidemiology


  • Pancreatic cancer
  • Smoking
  • Smoking cessation


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