The Association of Ovarian Reserve with Exposure to Bisphenol A and Phthalate in Reproductive-aged Women

So Yun Park, Ji Hyun Jeon, Kyungah Jeong, Hye Won Chung, Hyejin Lee, Yeon Ah Sung, Shinhee Ye, Eun Hee Ha

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21 Scopus citations


Background: Exposure to endocrine disrupting chemicals (EDCs) that influence the hormonal and homeostatic systems is known to be associated with gynecologic health risks in many countries. In this study, we evaluated exposure to EDCs associated with diminished ovarian reserve (DOR) and gynecologic health risks. Methods: This cross-sectional study was performed from September 2014 to November 2014 and included 307 Korean reproductive-aged women. Anthropometric measurements, laboratory tests with urine and blood sampling and pelvic ultrasound examinations were performed. Results: Urinary bisphenol A (BLA) level was significantly higher in the DOR group with anti-Miillerian hormone lower than 25 percentile (1.89 ± 2.17 ug/g and 1.58 ± 1.08 ug/g, P < 0.05). Urinary mono-(2-ethyl-5-hydroxyhexyl) phthalate, mono-(2-ethyl-5-oxohexyl) phthalate and mono-N-buty1 phthalate, and substrates of phthalate were evaluated and no significant difference was observed between the DOR group and non-DOR group. Logistic regression analysis suggested an increase in infertility in high BPA exposure group and the odds ratio (OR, 4.248) was statistically significant after adjustment for age, birth control pills, and the age of menarche, parity, and waist circumference. High phthalate exposure was associated with endometrial polyp after adjustment (OR, 2.742). Conclusion: BPA exposure might be associated with DOR and infertility. Meanwhile, endometrial polyp is increased in women with high phthalate exposure. Therefore, the risk of exposures to EDCs for reproduction should be a matter of concern in reproductive-aged women.

Original languageEnglish
Article numbere1
JournalJournal of Korean Medical Science
Issue number2
StatePublished - Jan 2021

Bibliographical note

Funding Information:
This work was supported by the Ministry of Environment, Republic of Korea (2014).

Publisher Copyright:
© 2021 The Korean Academy of Medical Sciences. All rights reserved.


  • Bisphenol A
  • Diminished Ovarian Reserve
  • Endocrine Disrupting Chemicals
  • Phthalate


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