The anticancer effect of natural plant alkaloid isoquinolines

Dahye Yun; So Young Yoon; Soo Jung Park; Yoon Jung Park

doi:10.3390/ijms22041653

The anticancer effect of natural plant alkaloid isoquinolines

Dahye Yun, So Young Yoon, Soo Jung Park, Yoon Jung Park

Department of Nutritional Science & Food Management

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apopto-sis, and autophagy, leading to cell death. While the molecular mechanisms of these effects are not fully understood, it has been suggested that binding to nucleic acids or proteins, enzyme inhibition, and epigenetic modulation by isoquinoline alkaloids may play a role in the effects. This review discusses recent evidence on the molecular mechanisms by which the isoquinoline alkaloids can be a therapeutic target of cancer treatment.

Original language	English
Article number	1653
Pages (from-to)	1-15
Number of pages	15
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	4
DOIs	https://doi.org/10.3390/ijms22041653
State	Published - 2 Feb 2021

Keywords

Anticancer
Apoptosis
Autophagy
Cell cycle arrest
Epigenetic regulation
Isoquinoline alkaloids

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10.3390/ijms22041653

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title = "The anticancer effect of natural plant alkaloid isoquinolines",

abstract = "Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apopto-sis, and autophagy, leading to cell death. While the molecular mechanisms of these effects are not fully understood, it has been suggested that binding to nucleic acids or proteins, enzyme inhibition, and epigenetic modulation by isoquinoline alkaloids may play a role in the effects. This review discusses recent evidence on the molecular mechanisms by which the isoquinoline alkaloids can be a therapeutic target of cancer treatment.",

keywords = "Anticancer, Apoptosis, Autophagy, Cell cycle arrest, Epigenetic regulation, Isoquinoline alkaloids",

author = "Dahye Yun and Yoon, {So Young} and Park, {Soo Jung} and Park, {Yoon Jung}",

note = "Funding Information: This research was funded by the National Research Foundation of Korea (2018R1D1A1B07051274 to Y.J.P.; 2020R1F1A1076181 to S.J.P.) and Brain Korea Four Project (Education Research Center for 4IR-Based Health Care). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Park, Soo Jung

AU - Park, Yoon Jung

N1 - Funding Information: This research was funded by the National Research Foundation of Korea (2018R1D1A1B07051274 to Y.J.P.; 2020R1F1A1076181 to S.J.P.) and Brain Korea Four Project (Education Research Center for 4IR-Based Health Care). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/2/2

Y1 - 2021/2/2

N2 - Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apopto-sis, and autophagy, leading to cell death. While the molecular mechanisms of these effects are not fully understood, it has been suggested that binding to nucleic acids or proteins, enzyme inhibition, and epigenetic modulation by isoquinoline alkaloids may play a role in the effects. This review discusses recent evidence on the molecular mechanisms by which the isoquinoline alkaloids can be a therapeutic target of cancer treatment.

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The anticancer effect of natural plant alkaloid isoquinolines

Abstract

Keywords

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