The [1,5]-Brook rearrangement: An initial application in anion relay chemistry

Amos B. Smith, Ming Xian, Won Suk Kim, Dae Shik Kim

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


The [1,5]-Brook rearrangement proceeds efficiently in a series of hydroxyl dithiane substrates with sodium and potassium bases; less effective are lithium bases. That the mode of silyl migration is intramolecular was demonstrated by a crossover experiment. Finally, the tricomponent anion relay chemistry (ARC) coupling tactic was demonstrated employing the [1,5]-Brook rearrangement.

Original languageEnglish
Pages (from-to)12368-12369
Number of pages2
JournalJournal of the American Chemical Society
Issue number38
StatePublished - 27 Sep 2006


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