Temporal modulation of optical energy for enhanced photothermal hemostasis of intraoperative bleeding during laser treatment

Suhyun Park, Hyun Wook Kang

Research output: Contribution to journalArticlepeer-review

Abstract

Intraoperative bleeding during laser treatment of benign prostate hyperplasia (BPH) often impedes cystoscopic vision, necessitating the use of conventional hemostatic devices. This study proposes an optical technique to improve the efficacy of photothermal hemostasis of bleeders during laser prostatectomy by temporally modulating a 532 nm laser beam. A perfused porcine kidney model is established to quantitatively investigate various optical pulse patterns and irradiation modes. Thermal simulations demonstrate a high success rate of complete hemostasis achieved by the modulated 532 nm pulse pattern. In comparison to the irradiation modes typically employed for hemostasis, the modulated 532 nm mode exhibits a short coagulation time and minimal thermal injury. ex vivo and in vivo cystoscopic observations validate the clinical feasibility of the proposed optical energy modulation method to regulate intraoperative bleeding.

Original languageEnglish
Article numbere202000086
JournalJournal of Biophotonics
Volume13
Issue number8
DOIs
StatePublished - 1 Aug 2020

Keywords

  • benign prostate hyperplasia
  • energy modulation
  • perfused kidney model
  • photothermal hemostasis

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