Tcr transgenic mice: a valuable tool for studying viral immunopathogenesis mechanisms

Yong Bin Cho, In Gu Lee, Yong Hyun Joo, So Hee Hong, Young Jin Seo

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Viral infectious diseases are a significant burden on public health and the global economy, and new viral threats emerge continuously. Since CD4+ and CD8+ T cell responses are essential to eliminating viruses, it is important to understand the underlying mechanisms of anti-viral T cell-mediated immunopathogenesis during viral infections. Remarkable progress in transgenic (Tg) techniques has enabled scientists to more readily understand the mechanisms of viral pathogenesis. T cell receptor (TCR) Tg mice are extremely useful in studying T cell-mediated immune responses because the majority of T cells in these mice express specific TCRs for partner antigens. In this review, we discuss the important studies utilizing TCR Tg mice to unveil underlying mechanisms of T cell-mediated immunopathogenesis during viral infections.

Original languageEnglish
Article number9690
Pages (from-to)1-12
Number of pages12
JournalInternational Journal of Molecular Sciences
Volume21
Issue number24
DOIs
StatePublished - 2 Dec 2020

Keywords

  • Immunopathogenesis
  • T cell
  • TCR transgenic mice
  • Viral infection

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