Targeting the transforming growth factor-β signaling in cancer therapy

Yhun Yhong Sheen; Min Jin Kim; Sang A. Park; So Yeon Park; Jeong Seok Nam

doi:10.4062/biomolther.2013.072

Targeting the transforming growth factor-β signaling in cancer therapy

Yhun Yhong Sheen, Min Jin Kim, Sang A. Park, So Yeon Park, Jeong Seok Nam

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Review article › peer-review

102 Scopus citations

Abstract

TGF-β pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-β (TGF-β) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-β related functional contexts. This review discusses the molecular mechanism of the TGF-β pathway and describes the different ways of tumor suppression and promotion by TGF-β. In the last part of the review, the data on targeting TGF-β pathway for cancer treatment is assessed. The TGF-β inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.

Original language	English
Pages (from-to)	323-331
Number of pages	9
Journal	Biomolecules and Therapeutics
Volume	21
Issue number	5
DOIs	https://doi.org/10.4062/biomolther.2013.072
State	Published - 2013

Keywords

ALK5
Breast cancer
EW-7197
Metastasis
Transforming growth factor-β(TGF-β)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4062/biomolther.2013.072

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@article{b52e9973536a45999772df82540fd454,

title = "Targeting the transforming growth factor-β signaling in cancer therapy",

abstract = "TGF-β pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-β (TGF-β) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-β related functional contexts. This review discusses the molecular mechanism of the TGF-β pathway and describes the different ways of tumor suppression and promotion by TGF-β. In the last part of the review, the data on targeting TGF-β pathway for cancer treatment is assessed. The TGF-β inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.",

keywords = "ALK5, Breast cancer, EW-7197, Metastasis, Transforming growth factor-β(TGF-β)",

author = "Sheen, \{Yhun Yhong\} and Kim, \{Min Jin\} and Park, \{Sang A.\} and Park, \{So Yeon\} and Nam, \{Jeong Seok\}",

year = "2013",

doi = "10.4062/biomolther.2013.072",

language = "English",

volume = "21",

pages = "323--331",

journal = "Biomolecules and Therapeutics",

issn = "1976-9148",

publisher = "Korean Society of Applied Pharmacology",

number = "5",

}

TY - JOUR

T1 - Targeting the transforming growth factor-β signaling in cancer therapy

AU - Sheen, Yhun Yhong

AU - Kim, Min Jin

AU - Park, Sang A.

AU - Park, So Yeon

AU - Nam, Jeong Seok

PY - 2013

Y1 - 2013

N2 - TGF-β pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-β (TGF-β) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-β related functional contexts. This review discusses the molecular mechanism of the TGF-β pathway and describes the different ways of tumor suppression and promotion by TGF-β. In the last part of the review, the data on targeting TGF-β pathway for cancer treatment is assessed. The TGF-β inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.

AB - TGF-β pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-β (TGF-β) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-β related functional contexts. This review discusses the molecular mechanism of the TGF-β pathway and describes the different ways of tumor suppression and promotion by TGF-β. In the last part of the review, the data on targeting TGF-β pathway for cancer treatment is assessed. The TGF-β inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.

KW - ALK5

KW - Breast cancer

KW - EW-7197

KW - Metastasis

KW - Transforming growth factor-β(TGF-β)

UR - https://www.scopus.com/pages/publications/84885063519

U2 - 10.4062/biomolther.2013.072

DO - 10.4062/biomolther.2013.072

M3 - Review article

AN - SCOPUS:84885063519

SN - 1976-9148

VL - 21

SP - 323

EP - 331

JO - Biomolecules and Therapeutics

JF - Biomolecules and Therapeutics

IS - 5

ER -

Targeting the transforming growth factor-β signaling in cancer therapy

Abstract

Keywords

UN SDGs

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