Abstract
TGF-β pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-β (TGF-β) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-β related functional contexts. This review discusses the molecular mechanism of the TGF-β pathway and describes the different ways of tumor suppression and promotion by TGF-β. In the last part of the review, the data on targeting TGF-β pathway for cancer treatment is assessed. The TGF-β inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.
| Original language | English |
|---|---|
| Pages (from-to) | 323-331 |
| Number of pages | 9 |
| Journal | Biomolecules and Therapeutics |
| Volume | 21 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2013 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- ALK5
- Breast cancer
- EW-7197
- Metastasis
- Transforming growth factor-β(TGF-β)
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