TY - JOUR
T1 - Targeting syndecans
T2 - A promising strategy for the treatment of cancer
AU - Choi, Sojoong
AU - Kang, Duk Hee
AU - Oh, Eok Soo
N1 - Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MEST) (No. 2012R1A5A1048236) and a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A120071).
PY - 2013/6
Y1 - 2013/6
N2 - Introduction: Syndecans are cell surface adhesion receptors that play important functional roles. Their deregulation has been linked to several pathologies, and their aberrant regulation via diverse mechanisms is critically involved in the pathogenesis of various cancers. Similar to other receptors, syndecan functions are altered by ligand binding, overexpression, and extracellular domain shedding. These regulatory mechanisms may suggest new strategies for specifically controlling cancer cells. Areas covered: In this review, we describe the biological functions of syndecans in cancer, discuss their potential therapeutic relevance, and examine the current syndecan-targeting therapeutic options. Expert opinion: Since syndecans have diverse, specific, and novel regulatory functions in various cancers, therapeutic control of syndecan function has become an attractive approach for potential anticancer strategies. Syndecan and its associated proteins may also be strong candidate markers for the diagnosis and management of cancer, potentially opening a new era in cancer treatment.
AB - Introduction: Syndecans are cell surface adhesion receptors that play important functional roles. Their deregulation has been linked to several pathologies, and their aberrant regulation via diverse mechanisms is critically involved in the pathogenesis of various cancers. Similar to other receptors, syndecan functions are altered by ligand binding, overexpression, and extracellular domain shedding. These regulatory mechanisms may suggest new strategies for specifically controlling cancer cells. Areas covered: In this review, we describe the biological functions of syndecans in cancer, discuss their potential therapeutic relevance, and examine the current syndecan-targeting therapeutic options. Expert opinion: Since syndecans have diverse, specific, and novel regulatory functions in various cancers, therapeutic control of syndecan function has become an attractive approach for potential anticancer strategies. Syndecan and its associated proteins may also be strong candidate markers for the diagnosis and management of cancer, potentially opening a new era in cancer treatment.
KW - Cancer
KW - Cancer therapy
KW - Extracellular matrix
KW - Syndecan
KW - Syndecan shedding
KW - Syndecan-mediated signal transduction
UR - http://www.scopus.com/inward/record.url?scp=84877857321&partnerID=8YFLogxK
U2 - 10.1517/14728222.2013.773313
DO - 10.1517/14728222.2013.773313
M3 - Review article
C2 - 23421390
AN - SCOPUS:84877857321
SN - 1472-8222
VL - 17
SP - 695
EP - 705
JO - Expert Opinion on Therapeutic Targets
JF - Expert Opinion on Therapeutic Targets
IS - 6
ER -