Targeting heat shock protein 27 in cancer: A druggable target for cancer treatment?

Choi Seul-Ki, Heejin Kam, Kim Kye-Young, Suk In Park, Lee Yun-Sil

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations

Abstract

Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a significant role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with a poor prognosis, as well as treatment resistance, whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as the strategies for using HSP27 inhibitors for therapeutic purposes.

Original languageEnglish
Article number1195
JournalCancers
Volume11
Issue number8
DOIs
StatePublished - Aug 2019

Bibliographical note

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Anti-cancer drugs
  • HSP27 inhibitor
  • Heat shock protein 27
  • Resistance

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