Targeting heat shock protein 27 in cancer: A druggable target for cancer treatment?

Choi Seul-Ki; Heejin Kam; Kim Kye-Young; Suk In Park; Lee Yun-Sil

doi:10.3390/cancers11081195

Targeting heat shock protein 27 in cancer: A druggable target for cancer treatment?

Choi Seul-Ki, Heejin Kam, Kim Kye-Young, Suk In Park, Lee Yun-Sil

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Review article › peer-review

85 Scopus citations

Abstract

Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a significant role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with a poor prognosis, as well as treatment resistance, whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as the strategies for using HSP27 inhibitors for therapeutic purposes.

Original language	English
Article number	1195
Journal	Cancers
Volume	11
Issue number	8
DOIs	https://doi.org/10.3390/cancers11081195
State	Published - Aug 2019

Bibliographical note

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Anti-cancer drugs
HSP27 inhibitor
Heat shock protein 27
Resistance

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title = "Targeting heat shock protein 27 in cancer: A druggable target for cancer treatment?",

abstract = "Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a significant role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with a poor prognosis, as well as treatment resistance, whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as the strategies for using HSP27 inhibitors for therapeutic purposes.",

keywords = "Anti-cancer drugs, HSP27 inhibitor, Heat shock protein 27, Resistance",

author = "Choi Seul-Ki and Heejin Kam and Kim Kye-Young and {In Park}, Suk and Lee Yun-Sil",

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year = "2019",

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language = "English",

volume = "11",

journal = "Cancers",

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T1 - Targeting heat shock protein 27 in cancer

T2 - A druggable target for cancer treatment?

AU - Seul-Ki, Choi

AU - Kam, Heejin

AU - Kye-Young, Kim

AU - In Park, Suk

AU - Yun-Sil, Lee

PY - 2019/8

Y1 - 2019/8

N2 - Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a significant role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with a poor prognosis, as well as treatment resistance, whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as the strategies for using HSP27 inhibitors for therapeutic purposes.

AB - Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a significant role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with a poor prognosis, as well as treatment resistance, whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as the strategies for using HSP27 inhibitors for therapeutic purposes.

KW - Anti-cancer drugs

KW - HSP27 inhibitor

KW - Heat shock protein 27

KW - Resistance

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U2 - 10.3390/cancers11081195

DO - 10.3390/cancers11081195

M3 - Review article

AN - SCOPUS:85071778793

SN - 2072-6694

VL - 11

JO - Cancers

JF - Cancers

IS - 8

M1 - 1195

ER -

Targeting heat shock protein 27 in cancer: A druggable target for cancer treatment?

Abstract

Bibliographical note

Keywords

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