@article{020f23d178aa46a4b9792eed38409fc3,
title = "Targeted Discovery of an Enediyne-Derived Cycloaromatized Compound, Jejucarboside A, from a Marine Actinomycete",
abstract = "A genomic and spectroscopic signature-based search revealed a cycloaromatized enediyne, jejucarboside A (1), from a marine actinomycete strain. The structure of 1 was determined as a new cyclopenta[a]indene glycoside bearing carbonate functionality by nuclear magnetic resonance, high-resolution mass spectrometry (MS), MS/MS, infrared spectroscopy, and a modified Mosher's method. An iterative enediyne synthase pathway has been proposed for the putative biosynthesis of 1 by genomic analysis. Jejucarboside A exhibited cytotoxicity against the HCT116 colon carcinoma cells.",
author = "Im, {Ji Hyeon} and Daniel Shin and Ban, {Yeon Hee} and Byun, {Woong Sub} and Bae, {Eun Seo} and Donghoon Lee and Du, {Young Eun} and Jinsheng Cui and Yun Kwon and Nam, {Sang Jip} and Sangwon Cha and Lee, {Sang Kook} and Yoon, {Yeo Joon} and Oh, {Dong Chan}",
note = "Funding Information: This work was supported by the National Research Foundation of Korea grants funded by the Republic of Korean Government (Ministry of Science and ICT) (2021R1A4A2001251, 2022R1A2C3004621, and 2020R1A2C2003518). Publisher Copyright: {\textcopyright} 2022 American Chemical Society. All rights reserved.",
year = "2022",
month = oct,
day = "7",
doi = "10.1021/acs.orglett.2c02934",
language = "English",
volume = "24",
pages = "7188--7193",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "39",
}
