Abstract
A tandem one-pot method for the construction of polysubstituted pyridines with complete control of the substitution pattern has been developed. The zinc bromide β-enamino ester intermediates of the Blaise reaction of simple nitriles with a Reformatsky reagent undergo Michael addition with conjugated ketones in the presence of a catalytic amount of In(OTf)3. Final intramolecular cyclization and oxidative aromatization yields polysubstituted pyridines in this tandem one-pot cascade.
Original language | English |
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Pages (from-to) | 1108-1112 |
Number of pages | 5 |
Journal | Asian Journal of Organic Chemistry |
Volume | 3 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2014 |
Bibliographical note
Publisher Copyright:© 2014 Wiley-VCH Verlag GmbH & Co.
Keywords
- Blaise reaction
- Indium
- Pyridines
- Reformatsky reagent
- α,β-unsaturated ketones