Abstract
A tandem one-pot method for the construction of a pyridine moiety with selective control of substitution patterns has been developed through the sequential reactions of nitrile with a Reformatsky reagent and 1,3-enyne involving regio- and chemoselective addition of the Blaise reaction intermediate to 1,3-enyne, followed by isomerization, cyclization, and an aromatization cascade.
Original language | English |
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Pages (from-to) | 6390-6393 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 13 |
Issue number | 24 |
DOIs | |
State | Published - 16 Dec 2011 |