Tandem one-pot synthesis of polysubstituted pyridines using the blaise reaction intermediate and 1,3-enynes

Yu Sung Chun, Jun Hee Lee, Ju Hyun Kim, Young Ok Ko, Sang Gi Lee

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

A tandem one-pot method for the construction of a pyridine moiety with selective control of substitution patterns has been developed through the sequential reactions of nitrile with a Reformatsky reagent and 1,3-enyne involving regio- and chemoselective addition of the Blaise reaction intermediate to 1,3-enyne, followed by isomerization, cyclization, and an aromatization cascade.

Original languageEnglish
Pages (from-to)6390-6393
Number of pages4
JournalOrganic Letters
Volume13
Issue number24
DOIs
StatePublished - 16 Dec 2011

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