Abstract
A novel Pd-catalyzed Ullmann-type homocoupling reaction of the Blaise reaction intermediate generated by the reaction of 2-bromo arylnitriles and a Reformatsky reagent has been developed for one-pot synthesis of enamino ester-functionalized biaryls 2 in good yields. The 2,2′-substituted enamine moieties of the coupling products could be cyclized under acidic conditions through the conjugate addition/deamination cascade to afford the seven-membered N-heterocyclics 3 with biaryl backbone in excellent yields.
Original language | English |
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Pages (from-to) | 7824-7829 |
Number of pages | 6 |
Journal | Journal of Organic Chemistry |
Volume | 80 |
Issue number | 15 |
DOIs | |
State | Published - 7 Aug 2015 |
Bibliographical note
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