Tandem Blaise-Nenitzescu reaction: One-pot synthesis of 5-hydroxy-α-(aminomethylene)benzofuran-2(3H)-ones from nitriles

Yu Sung Chun, Ka Yeon Ryu, Ju Hyun Kim, Hyunik Shin, Sang Gi Lee

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

In contrast to the reaction of benzoquinones with β-enaminoesters providing indoles (Nenitzescu reaction), the tandem one-pot reaction of the Blaise reaction intermediate, zinc bromide complex of β-enaminoesters, with benzoquinone affords 5-hydroxy-α-(aminomethylene)benzofuran-2(3H)-ones in good to excellent yields (tandem Blaise-Nenitzescu reaction).

Original languageEnglish
Pages (from-to)1317-1319
Number of pages3
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number5
DOIs
StatePublished - 1 Mar 2011

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