Tandem blaise-alkenylation with unactivated alkynes: One-pot synthesis of α-vinylated β-enaminoesters from nitriles

Yu Sung Chun; Young Ok Ko; Hyunik Shin; Sang Gi Lee

doi:10.1021/ol901241s

Tandem blaise-alkenylation with unactivated alkynes: One-pot synthesis of α-vinylated β-enaminoesters from nitriles

Yu Sung Chun, Young Ok Ko, Hyunik Shin, Sang Gi Lee

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

The in situ generated Blaise reaction intermediate, a zinc bromide complex of β-enaminoester, reacts with various unactivated terminal alkynes and an internal alkyne under mild conditions to afford α-vinylated β-enaminoesters in good to excellent yields.

Original language	English
Pages (from-to)	3414-3417
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	15
DOIs	https://doi.org/10.1021/ol901241s
State	Published - 6 Aug 2009

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@article{b273281e638a42458d907a398869a402,

title = "Tandem blaise-alkenylation with unactivated alkynes: One-pot synthesis of α-vinylated β-enaminoesters from nitriles",

abstract = "The in situ generated Blaise reaction intermediate, a zinc bromide complex of β-enaminoester, reacts with various unactivated terminal alkynes and an internal alkyne under mild conditions to afford α-vinylated β-enaminoesters in good to excellent yields.",

author = "Chun, \{Yu Sung\} and Ko, \{Young Ok\} and Hyunik Shin and Lee, \{Sang Gi\}",

year = "2009",

month = aug,

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doi = "10.1021/ol901241s",

language = "English",

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journal = "Organic Letters",

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TY - JOUR

T1 - Tandem blaise-alkenylation with unactivated alkynes

T2 - One-pot synthesis of α-vinylated β-enaminoesters from nitriles

AU - Chun, Yu Sung

AU - Ko, Young Ok

AU - Shin, Hyunik

AU - Lee, Sang Gi

PY - 2009/8/6

Y1 - 2009/8/6

N2 - The in situ generated Blaise reaction intermediate, a zinc bromide complex of β-enaminoester, reacts with various unactivated terminal alkynes and an internal alkyne under mild conditions to afford α-vinylated β-enaminoesters in good to excellent yields.

AB - The in situ generated Blaise reaction intermediate, a zinc bromide complex of β-enaminoester, reacts with various unactivated terminal alkynes and an internal alkyne under mild conditions to afford α-vinylated β-enaminoesters in good to excellent yields.

UR - https://www.scopus.com/pages/publications/68149087630

U2 - 10.1021/ol901241s

DO - 10.1021/ol901241s

M3 - Article

C2 - 19572602

AN - SCOPUS:68149087630

SN - 1523-7060

VL - 11

SP - 3414

EP - 3417

JO - Organic Letters

JF - Organic Letters

IS - 15

ER -

Tandem blaise-alkenylation with unactivated alkynes: One-pot synthesis of α-vinylated β-enaminoesters from nitriles

Abstract

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