T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3

Eun Sook Hwang, Susanne J. Szabo, Pamela L. Schwartzberg, Laurie H. Glimcher

Research output: Contribution to journalArticlepeer-review

413 Scopus citations

Abstract

Cell lineage specification depends on both gene activation and gene silencing, and in the differentiation of T helper progenitors to Th1 or Th2 effector cells, this requires the action of two opposing transcription factors, T-bet and GATA-3. T-bet is essential for the development of Th1 cells, and GATA-3 performs an equivalent role in Th2 development. We report that T-bet represses Th2 lineage commitment through tyrosine kinase-mediated interaction between the two transcription factors that interferes with the binding of GATA-3 to its target DNA. These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell.

Original languageEnglish
Pages (from-to)430-433
Number of pages4
JournalScience
Volume307
Issue number5708
DOIs
StatePublished - 21 Jan 2005

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