Systemic and brain delivery of antidiabetic peptides through nasal administration using cell-penetrating peptides

Jeehye Maeng, Kyunglim Lee

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


The intranasal route has emerged as a promising strategy that can direct delivery of drugs into the systemic circulation because the high-vascularized nasal cavity, among other advantages, avoids the hepatic first-pass metabolism. The nose-to-brain pathway provides a non-invasive alternative to other routes for the delivery of macromolecular therapeutics. A great variety of methodologies has been developed to enhance the efficiency of transepithelial translocation of macromolecules. Among these, the use of cell-penetrating peptides (CPPs), short protein transduction domains (PTDs) that facilitate the intracellular transport of various bioactive molecules, has become an area of extensive research in the intranasal delivery of peptides and proteins either to systemic or to brain compartments. Some CPPs have been applied for the delivery of peptide antidiabetics, including insulin and exendin-4, for treating diabetes and Alzheimer’s disease. This review highlights the current status of CPP-driven intranasal delivery of peptide drugs and its potential applicability as a universal vehicle in the nasal drug delivery.

Original languageEnglish
Article number1068495
JournalFrontiers in Pharmacology
StatePublished - 14 Nov 2022

Bibliographical note

Funding Information:
This research was supported by the Bio and Medical Technology Development Program (2020M3E5E2036808) and (2021R1A2C2003629) by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT).

Publisher Copyright:
Copyright © 2022 Maeng and Lee.


  • antidiabetic peptides
  • cell-penetrating peptide
  • CPP
  • nasal delivery
  • nose-to-brain delivery
  • protein transduction domain
  • PTD


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