Systematic analysis of the pharmacological function of Schisandra as a potential exercise supplement

Bok Sil Hong, Suji Baek, Myoung Ryu Kim, Sun Mi Park, Bom Sahn Kim, Jisu Kim, Kang Pa Lee

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


[Purpose] Exercise can prevent conditions such as atrophy and degenerative brain diseases. However, owing to individual differences in athletic ability, exercise supplements can be used to improve a person’s exercise capacity. Schisandra chinensis (SC) is a natural product with various physiologically active effects. In this study, we analyzed SC using a pharmacological network and determined whether it could be used as an exercise supplement. [Methods] The active compounds of SC and target genes were identified using the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). The active compound and target genes were selected based on pharmacokinetic (PK) conditions (oral bioavailability (OB) ≥ 30%, Caco-2 permeability (Caco-2) ≥ -0.4, and drug-likeness (DL) ≥ 0.18). Gene ontology (GO) was analyzed using the Cytoscape software. [Results] Eight active compounds were identified according to the PK conditions. Twenty-one target genes were identified after excluding duplicates in the eight active compounds. The top 10 GOs were analyzed using GO-biological process analysis. GO was subsequently divided into three representative categories: postsynaptic neurotransmitter receptor activity (53.85%), an intracellular steroid hormone receptor signaling pathway (36.46%), and endopeptidase activity (10%). SC is related to immune function. [Conclusion] According to the GO analysis, SC plays a role in immunity and inflammation, promotes liver metabolism, improves fatigue, and regulates the function of steroid receptors. Therefore, we suggest SC as an exercise supplement with nutritional and anti-fatigue benefits.

Original languageEnglish
Pages (from-to)38-44
Number of pages7
JournalPhysical Activity and Nutrition
Issue number4
StatePublished - 1 Dec 2021

Bibliographical note

Publisher Copyright:
©2021 Bok Sil Hong et al.; ©2021 The Korean Society for Exercise Nutrition.


  • Schizandra chinensis
  • anti-fatigue
  • exercise supplement
  • immune system
  • liver metabolism
  • neurotransmitter


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