Synthetic GPI array to study antitoxic malaria response

Faustin Kamena; Marco Tamborrini; Xinyu Liu; Yong Uk Kwon; Fiona Thompson; Gerd Pluschke; Peter H. Seeberger

doi:10.1038/nchembio.75

Synthetic GPI array to study antitoxic malaria response

Faustin Kamena, Marco Tamborrini, Xinyu Liu, Yong Uk Kwon, Fiona Thompson, Gerd Pluschke, Peter H. Seeberger

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

Abstract

Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine. We present a versatile approach based on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria.

Original language	English
Pages (from-to)	238-240
Number of pages	3
Journal	Nature Chemical Biology
Volume	4
Issue number	4
DOIs	https://doi.org/10.1038/nchembio.75
State	Published - Apr 2008

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10.1038/nchembio.75

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abstract = "Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine. We present a versatile approach based on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria.",

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AU - Kamena, Faustin

AU - Tamborrini, Marco

AU - Liu, Xinyu

AU - Kwon, Yong Uk

AU - Thompson, Fiona

AU - Pluschke, Gerd

AU - Seeberger, Peter H.

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AB - Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine. We present a versatile approach based on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria.

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VL - 4

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Synthetic GPI array to study antitoxic malaria response

Abstract

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