Abstract
Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine. We present a versatile approach based on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria.
Original language | English |
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Pages (from-to) | 238-240 |
Number of pages | 3 |
Journal | Nature Chemical Biology |
Volume | 4 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2008 |