Synthetic GPI array to study antitoxic malaria response

Faustin Kamena, Marco Tamborrini, Xinyu Liu, Yong Uk Kwon, Fiona Thompson, Gerd Pluschke, Peter H. Seeberger

Research output: Contribution to journalArticlepeer-review

107 Scopus citations

Abstract

Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine. We present a versatile approach based on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria.

Original languageEnglish
Pages (from-to)238-240
Number of pages3
JournalNature Chemical Biology
Volume4
Issue number4
DOIs
StatePublished - Apr 2008

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