TY - JOUR
T1 - Synthesis, structure, and antitumor activity of 1,3-dithiol- and 1,3-dithiolan-2-ylidenemalonatoplatinum(II) complexes
AU - Sohn, Youn Soo
AU - Kim, Kwan Mook
AU - Jeong, Jong Hwa
AU - Noh, Dong Youn
AU - Lee, Chong Ock
AU - Choi, Sang Un
N1 - Funding Information:
This research was supported financially by the Ministry of Science and Technologyi n Korea.
PY - 1994/5/1
Y1 - 1994/5/1
N2 - 1,3-Dithiol- and 1,3-dithiolan-2-ylidenemalonatoplatinum(II) complexes A2Pt(OOC)2 CR2 (A = NH3, cyclopropylamine (CPA) or A2 = ethylenediamine(EDA), trans(±)-1,2-diaminocyclohexane(DACH); R2 = -SCH CHS-, -SCH2CH2S-) have been synthesized and subjected to in vivo assay for antitumor activity after characterization by means of elemental analysis, IR spectroscopy, and x-ray analysis. The molecular structure of (CPA)2Pt(OOC)2C CSCH CHS has been determined by x-ray diffraction: space group P21/n, a = 7.955(1), b= 16.912(2), c = 15.116(2) Å, β = 102.74(1)°, z = 4, R = 0.032, Rw = 0.035. Among the Pt(II) complexes studied, biscyclopropylamineplatinum(II) complexes both of the above-mentioned dicarboxylate leaving groups exhibited much higher antitumor activity against the leukemia L1210 cell line compared with the known cisplatin.
AB - 1,3-Dithiol- and 1,3-dithiolan-2-ylidenemalonatoplatinum(II) complexes A2Pt(OOC)2 CR2 (A = NH3, cyclopropylamine (CPA) or A2 = ethylenediamine(EDA), trans(±)-1,2-diaminocyclohexane(DACH); R2 = -SCH CHS-, -SCH2CH2S-) have been synthesized and subjected to in vivo assay for antitumor activity after characterization by means of elemental analysis, IR spectroscopy, and x-ray analysis. The molecular structure of (CPA)2Pt(OOC)2C CSCH CHS has been determined by x-ray diffraction: space group P21/n, a = 7.955(1), b= 16.912(2), c = 15.116(2) Å, β = 102.74(1)°, z = 4, R = 0.032, Rw = 0.035. Among the Pt(II) complexes studied, biscyclopropylamineplatinum(II) complexes both of the above-mentioned dicarboxylate leaving groups exhibited much higher antitumor activity against the leukemia L1210 cell line compared with the known cisplatin.
UR - http://www.scopus.com/inward/record.url?scp=0028338943&partnerID=8YFLogxK
U2 - 10.1016/0162-0134(94)80024-3
DO - 10.1016/0162-0134(94)80024-3
M3 - Article
C2 - 8176395
AN - SCOPUS:0028338943
SN - 0162-0134
VL - 54
SP - 107
EP - 114
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
IS - 2
ER -