TY - JOUR
T1 - Synthesis, structural characterization and biological evaluation of novel stilbene derivatives as potential antimalarial agents
AU - Jung, Mankil
AU - Park, Won Hwan
AU - Jung, Jae Chul
AU - Lim, Eunyoung
AU - Lee, Yongnam
AU - Oh, Seikwan
AU - Moon, Hyung In
PY - 2009/3
Y1 - 2009/3
N2 - A series of benzamide-containing stilbene derivatives was synthesized through the incorporation of short basic side-chains in the B-ring hydroxy position of resveratrol. Their antiplasmodial activity was evaluated in vitro against the chloroquine resistant Plasmodium falciparum D10 strain, showing IC50 values between 1.5 and 80 μm, while their cytotoxicity was assessed using an human myeloid leukemia (U-937) cell line. With a selectivity ratio of >51.02, the most selective of these derivatives, 29, also had the most lowest cytotoxic activity of the series.
AB - A series of benzamide-containing stilbene derivatives was synthesized through the incorporation of short basic side-chains in the B-ring hydroxy position of resveratrol. Their antiplasmodial activity was evaluated in vitro against the chloroquine resistant Plasmodium falciparum D10 strain, showing IC50 values between 1.5 and 80 μm, while their cytotoxicity was assessed using an human myeloid leukemia (U-937) cell line. With a selectivity ratio of >51.02, the most selective of these derivatives, 29, also had the most lowest cytotoxic activity of the series.
KW - Antiplasmodial activity
KW - Plasmodium falciparum
KW - Resveratrol
KW - Selectivity ratio
KW - Stilbene derivatives
UR - http://www.scopus.com/inward/record.url?scp=60349085069&partnerID=8YFLogxK
U2 - 10.1111/j.1747-0285.2009.00775.x
DO - 10.1111/j.1747-0285.2009.00775.x
M3 - Article
C2 - 19207471
AN - SCOPUS:60349085069
SN - 1747-0277
VL - 73
SP - 346
EP - 354
JO - Chemical Biology and Drug Design
JF - Chemical Biology and Drug Design
IS - 3
ER -