Synthesis, structural characterization and biological evaluation of novel stilbene derivatives as potential antimalarial agents

Mankil Jung, Won Hwan Park, Jae Chul Jung, Eunyoung Lim, Yongnam Lee, Seikwan Oh, Hyung In Moon

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A series of benzamide-containing stilbene derivatives was synthesized through the incorporation of short basic side-chains in the B-ring hydroxy position of resveratrol. Their antiplasmodial activity was evaluated in vitro against the chloroquine resistant Plasmodium falciparum D10 strain, showing IC50 values between 1.5 and 80 μm, while their cytotoxicity was assessed using an human myeloid leukemia (U-937) cell line. With a selectivity ratio of >51.02, the most selective of these derivatives, 29, also had the most lowest cytotoxic activity of the series.

Original languageEnglish
Pages (from-to)346-354
Number of pages9
JournalChemical Biology and Drug Design
Volume73
Issue number3
DOIs
StatePublished - Mar 2009

Keywords

  • Antiplasmodial activity
  • Plasmodium falciparum
  • Resveratrol
  • Selectivity ratio
  • Stilbene derivatives

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