Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase

Yong Uk Kwon; Jungkyun Im; Gildon Choi; Young Soo Kim; Kwan Yong Choi; Sung Kee Chung

doi:10.1016/S0960-894X(03)00629-2

Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase

Yong Uk Kwon
, Jungkyun Im
, Gildon Choi
, Young Soo Kim
, Kwan Yong Choi
, Sung Kee Chung

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

scyllo-Inositol phosphates, which are among the stereoisomers of myo-inositol phosphate, can have 15 possible regioisomers including three enantiomeric pairs: scyllo-I(1,2)P₂, scyllo-I(1,2,4)P₃, scyllo-I(1,2,3,4)P₄. We herein describe the facile synthetic routes to the three enantiomeric pairs of scyllo-inositol phosphate and the molecular interactions between 15 regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase. Geometry of the enzyme binding site is discussed.

Original language	English
Pages (from-to)	2981-2984
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	18
DOIs	https://doi.org/10.1016/S0960-894X(03)00629-2
State	Published - Sep 2003

Bibliographical note

Funding Information:
This work was financially supported by the Ministry of Education/Basic Science Research Institute fund, POSTECH/POSCO, and the KISTEP/NRL program.

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10.1016/S0960-894X(03)00629-2

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Kwon, Y. U., Im, J., Choi, G., Kim, Y. S., Choi, K. Y., & Chung, S. K. (2003). Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase. Bioorganic and Medicinal Chemistry Letters, 13(18), 2981-2984. https://doi.org/10.1016/S0960-894X(03)00629-2

@article{9dda876bbe70480d8391b5a858d04445,

title = "Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase",

abstract = "scyllo-Inositol phosphates, which are among the stereoisomers of myo-inositol phosphate, can have 15 possible regioisomers including three enantiomeric pairs: scyllo-I(1,2)P2, scyllo-I(1,2,4)P3, scyllo-I(1,2,3,4)P4. We herein describe the facile synthetic routes to the three enantiomeric pairs of scyllo-inositol phosphate and the molecular interactions between 15 regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase. Geometry of the enzyme binding site is discussed.",

author = "Kwon, \{Yong Uk\} and Jungkyun Im and Gildon Choi and Kim, \{Young Soo\} and Choi, \{Kwan Yong\} and Chung, \{Sung Kee\}",

note = "Funding Information: This work was financially supported by the Ministry of Education/Basic Science Research Institute fund, POSTECH/POSCO, and the KISTEP/NRL program.",

year = "2003",

month = sep,

doi = "10.1016/S0960-894X(03)00629-2",

language = "English",

volume = "13",

pages = "2981--2984",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "18",

}

Kwon, YU, Im, J, Choi, G, Kim, YS, Choi, KY & Chung, SK 2003, 'Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase', Bioorganic and Medicinal Chemistry Letters, vol. 13, no. 18, pp. 2981-2984. https://doi.org/10.1016/S0960-894X(03)00629-2

Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase. / Kwon, Yong Uk; Im, Jungkyun; Choi, Gildon et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 18, 09.2003, p. 2981-2984.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase

AU - Kwon, Yong Uk

AU - Im, Jungkyun

AU - Choi, Gildon

AU - Kim, Young Soo

AU - Choi, Kwan Yong

AU - Chung, Sung Kee

N1 - Funding Information: This work was financially supported by the Ministry of Education/Basic Science Research Institute fund, POSTECH/POSCO, and the KISTEP/NRL program.

PY - 2003/9

Y1 - 2003/9

N2 - scyllo-Inositol phosphates, which are among the stereoisomers of myo-inositol phosphate, can have 15 possible regioisomers including three enantiomeric pairs: scyllo-I(1,2)P2, scyllo-I(1,2,4)P3, scyllo-I(1,2,3,4)P4. We herein describe the facile synthetic routes to the three enantiomeric pairs of scyllo-inositol phosphate and the molecular interactions between 15 regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase. Geometry of the enzyme binding site is discussed.

AB - scyllo-Inositol phosphates, which are among the stereoisomers of myo-inositol phosphate, can have 15 possible regioisomers including three enantiomeric pairs: scyllo-I(1,2)P2, scyllo-I(1,2,4)P3, scyllo-I(1,2,3,4)P4. We herein describe the facile synthetic routes to the three enantiomeric pairs of scyllo-inositol phosphate and the molecular interactions between 15 regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase. Geometry of the enzyme binding site is discussed.

UR - https://www.scopus.com/pages/publications/0042521192

U2 - 10.1016/S0960-894X(03)00629-2

DO - 10.1016/S0960-894X(03)00629-2

M3 - Article

C2 - 12941316

AN - SCOPUS:0042521192

SN - 0960-894X

VL - 13

SP - 2981

EP - 2984

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 18

ER -

Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase

Abstract

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