TY - JOUR
T1 - Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase
AU - Kwon, Yong Uk
AU - Im, Jungkyun
AU - Choi, Gildon
AU - Kim, Young Soo
AU - Choi, Kwan Yong
AU - Chung, Sung Kee
N1 - Funding Information:
This work was financially supported by the Ministry of Education/Basic Science Research Institute fund, POSTECH/POSCO, and the KISTEP/NRL program.
PY - 2003/9
Y1 - 2003/9
N2 - scyllo-Inositol phosphates, which are among the stereoisomers of myo-inositol phosphate, can have 15 possible regioisomers including three enantiomeric pairs: scyllo-I(1,2)P2, scyllo-I(1,2,4)P3, scyllo-I(1,2,3,4)P4. We herein describe the facile synthetic routes to the three enantiomeric pairs of scyllo-inositol phosphate and the molecular interactions between 15 regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase. Geometry of the enzyme binding site is discussed.
AB - scyllo-Inositol phosphates, which are among the stereoisomers of myo-inositol phosphate, can have 15 possible regioisomers including three enantiomeric pairs: scyllo-I(1,2)P2, scyllo-I(1,2,4)P3, scyllo-I(1,2,3,4)P4. We herein describe the facile synthetic routes to the three enantiomeric pairs of scyllo-inositol phosphate and the molecular interactions between 15 regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase. Geometry of the enzyme binding site is discussed.
UR - https://www.scopus.com/pages/publications/0042521192
U2 - 10.1016/S0960-894X(03)00629-2
DO - 10.1016/S0960-894X(03)00629-2
M3 - Article
C2 - 12941316
AN - SCOPUS:0042521192
SN - 0960-894X
VL - 13
SP - 2981
EP - 2984
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 18
ER -