Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase

Yong Uk Kwon, Jungkyun Im, Gildon Choi, Young Soo Kim, Kwan Yong Choi, Sung Kee Chung

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Abstract

scyllo-Inositol phosphates, which are among the stereoisomers of myo-inositol phosphate, can have 15 possible regioisomers including three enantiomeric pairs: scyllo-I(1,2)P2, scyllo-I(1,2,4)P3, scyllo-I(1,2,3,4)P4. We herein describe the facile synthetic routes to the three enantiomeric pairs of scyllo-inositol phosphate and the molecular interactions between 15 regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase. Geometry of the enzyme binding site is discussed.

Original languageEnglish
Pages (from-to)2981-2984
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number18
DOIs
StatePublished - Sep 2003

Bibliographical note

Funding Information:
This work was financially supported by the Ministry of Education/Basic Science Research Institute fund, POSTECH/POSCO, and the KISTEP/NRL program.

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