Synthesis of the first water-soluble C2-symmetric bis(oxazolidinone) as a potential bifunctional chiral auxiliary

Sang Gi Lee, Chung Woo Lim, Dong Chan Kim, Jae Kyun Lee

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The first water-soluble C2-symmetric bis(oxazolidinone) 1, a potential bifunctional chiral auxiliary, has been synthesized via regioselective intramolecular cyclization of a biscarbamate. The sodium enolate derived from N,N'-di(phenylacetyl)bis(oxazolidinone) 7 reacts with methyl iodide with high facial selectivity (95:5). Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)1455-1458
Number of pages4
JournalTetrahedron Asymmetry
Volume11
Issue number7
DOIs
StatePublished - Apr 2000

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