Abstract
Two new kinds of docetaxel compound, with a mercapto group instead of the hydroxyl on the C13 side chain (both syn and anti), via the 7,10-di-(2,2,2- trichloroethyloxycarbonyl)-10-deacetylbaccatin III route, were synthesized. The uses of trans and cis oxazoline compounds, and their stereoselective ring-opening reactions with thiolacetic acid, were proved to be key steps.
Original language | English |
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Pages (from-to) | 4133-4138 |
Number of pages | 6 |
Journal | Tetrahedron |
Volume | 60 |
Issue number | 19 |
DOIs | |
State | Published - 3 May 2004 |
Bibliographical note
Funding Information:We thank Hanmi Pharmaceutical Co., Ltd for the generous donation of 10-deacetylbaccatin III. This work was supported by Korea Science and Engineering Foundation (R14-2003-014-01001-0) and the Brain Korea 21 Program.
Keywords
- Mercapto taxoid
- Oxazoline
- Taxol