@article{3729f68a4fff4bbc8490c12847b27db5,
title = "Synthesis of N,N′,N″-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor",
abstract = "Twenty-seven N,N′,N″-trisubstituted thiourea derivatives were prepared. Among them, 1-[3-(4′-hydroxy-3′-methoxy-phenyl)-propyl]-1,3-diphenethyl- thiourea (8l, IC50=0.32 μM), showed 2-fold higher antagonistic activity than that of capsazepine (3, IC50=0.65 μM) against the vanilloid receptor in a 45Ca2+-influx assay.",
author = "Park, {Hyeung Geun} and Park, {Mi Kyung} and Choi, {Ji Yeon} and Choi, {Sea Hoon} and Jihye Lee and Park, {Boon Saeng} and Kim, {Myoung Goo} and Suh, {Young Ger} and Hawon Cho and Uhtaek Oh and Jeewoo Lee and Kim, {Hee Doo} and Park, {Young Ho} and Koh, {Hyun Ju} and Lim, {Kyung Min} and Moh, {Joo Hyun} and Jew, {Sang Sup}",
note = "Funding Information: This research was supported by a grant from Amore Pacific Co. Ltd., Korea, and a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea: 02-PJ2-PG4-PT01-0014.",
year = "2003",
month = feb,
doi = "10.1016/S0960-894X(02)01040-5",
language = "English",
volume = "13",
pages = "601--604",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd.",
number = "4",
}