Synthesis of new xanthone analogues and their biological activity test-Cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study

Sangwook Woo; Ji Jung; Chongsoon Lee; Youngjoo Kwon; Younghwa Na

doi:10.1016/j.bmcl.2006.12.030

Synthesis of new xanthone analogues and their biological activity test-Cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study

Sangwook Woo
, Ji Jung
, Chongsoon Lee
, Youngjoo Kwon
, Younghwa Na

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

In this report, we prepared some 3-(2′,3′-epoxypropoxy)xanthones and their epoxide ring opened halohydrin analogues, and evaluated their cytotoxicity and topoisomerase II inhibition activity using doxorubicin and etoposide as references, respectively. Another xanthone compound 9, 1,3-di(2′,3′-epoxypropoxy)xanthone, was also synthesized and its DNA cross-linking property including other two biological activities investigated. The biological test results showed compound 9 possessed excellent cytotoxic and topoisomerase II inhibitory activity than other compounds tested. It also exhibited significant DNA cross-linking activities.

Original language	English
Pages (from-to)	1163-1166
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2006.12.030
State	Published - 1 Mar 2007

Bibliographical note

Funding Information:
This research was supported by research grant from Catholic University of Daegu, Korea in 2004.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-cancer agents
DNA cross-linking
Topoisomerase II inhibition
Xanthones

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10.1016/j.bmcl.2006.12.030

Cite this

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title = "Synthesis of new xanthone analogues and their biological activity test-Cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study",

abstract = "In this report, we prepared some 3-(2′,3′-epoxypropoxy)xanthones and their epoxide ring opened halohydrin analogues, and evaluated their cytotoxicity and topoisomerase II inhibition activity using doxorubicin and etoposide as references, respectively. Another xanthone compound 9, 1,3-di(2′,3′-epoxypropoxy)xanthone, was also synthesized and its DNA cross-linking property including other two biological activities investigated. The biological test results showed compound 9 possessed excellent cytotoxic and topoisomerase II inhibitory activity than other compounds tested. It also exhibited significant DNA cross-linking activities.",

keywords = "Anti-cancer agents, DNA cross-linking, Topoisomerase II inhibition, Xanthones",

author = "Sangwook Woo and Ji Jung and Chongsoon Lee and Youngjoo Kwon and Younghwa Na",

note = "Funding Information: This research was supported by research grant from Catholic University of Daegu, Korea in 2004. ",

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doi = "10.1016/j.bmcl.2006.12.030",

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T1 - Synthesis of new xanthone analogues and their biological activity test-Cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study

AU - Woo, Sangwook

AU - Jung, Ji

AU - Lee, Chongsoon

AU - Kwon, Youngjoo

AU - Na, Younghwa

N1 - Funding Information: This research was supported by research grant from Catholic University of Daegu, Korea in 2004.

PY - 2007/3/1

Y1 - 2007/3/1

N2 - In this report, we prepared some 3-(2′,3′-epoxypropoxy)xanthones and their epoxide ring opened halohydrin analogues, and evaluated their cytotoxicity and topoisomerase II inhibition activity using doxorubicin and etoposide as references, respectively. Another xanthone compound 9, 1,3-di(2′,3′-epoxypropoxy)xanthone, was also synthesized and its DNA cross-linking property including other two biological activities investigated. The biological test results showed compound 9 possessed excellent cytotoxic and topoisomerase II inhibitory activity than other compounds tested. It also exhibited significant DNA cross-linking activities.

AB - In this report, we prepared some 3-(2′,3′-epoxypropoxy)xanthones and their epoxide ring opened halohydrin analogues, and evaluated their cytotoxicity and topoisomerase II inhibition activity using doxorubicin and etoposide as references, respectively. Another xanthone compound 9, 1,3-di(2′,3′-epoxypropoxy)xanthone, was also synthesized and its DNA cross-linking property including other two biological activities investigated. The biological test results showed compound 9 possessed excellent cytotoxic and topoisomerase II inhibitory activity than other compounds tested. It also exhibited significant DNA cross-linking activities.

KW - Anti-cancer agents

KW - DNA cross-linking

KW - Topoisomerase II inhibition

KW - Xanthones

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DO - 10.1016/j.bmcl.2006.12.030

M3 - Article

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AN - SCOPUS:33846898056

SN - 0960-894X

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 5

ER -

Synthesis of new xanthone analogues and their biological activity test-Cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study

Abstract

Bibliographical note

UN SDGs

Keywords

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