Synthesis of new xanthone analogues and their biological activity test-Cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study

Sangwook Woo; Ji Jung; Chongsoon Lee; Youngjoo Kwon; Younghwa Na

doi:10.1016/j.bmcl.2006.12.030

Synthesis of new xanthone analogues and their biological activity test-Cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study

Sangwook Woo, Ji Jung, Chongsoon Lee, Youngjoo Kwon, Younghwa Na

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

In this report, we prepared some 3-(2′,3′-epoxypropoxy)xanthones and their epoxide ring opened halohydrin analogues, and evaluated their cytotoxicity and topoisomerase II inhibition activity using doxorubicin and etoposide as references, respectively. Another xanthone compound 9, 1,3-di(2′,3′-epoxypropoxy)xanthone, was also synthesized and its DNA cross-linking property including other two biological activities investigated. The biological test results showed compound 9 possessed excellent cytotoxic and topoisomerase II inhibitory activity than other compounds tested. It also exhibited significant DNA cross-linking activities.

Original language	English
Pages (from-to)	1163-1166
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2006.12.030
State	Published - 1 Mar 2007

Bibliographical note

Funding Information:
This research was supported by research grant from Catholic University of Daegu, Korea in 2004.

Keywords

Anti-cancer agents
DNA cross-linking
Topoisomerase II inhibition
Xanthones

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2006.12.030

Cite this

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title = "Synthesis of new xanthone analogues and their biological activity test-Cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study",

abstract = "In this report, we prepared some 3-(2′,3′-epoxypropoxy)xanthones and their epoxide ring opened halohydrin analogues, and evaluated their cytotoxicity and topoisomerase II inhibition activity using doxorubicin and etoposide as references, respectively. Another xanthone compound 9, 1,3-di(2′,3′-epoxypropoxy)xanthone, was also synthesized and its DNA cross-linking property including other two biological activities investigated. The biological test results showed compound 9 possessed excellent cytotoxic and topoisomerase II inhibitory activity than other compounds tested. It also exhibited significant DNA cross-linking activities.",

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AU - Woo, Sangwook

AU - Jung, Ji

AU - Lee, Chongsoon

AU - Kwon, Youngjoo

AU - Na, Younghwa

N1 - Funding Information: This research was supported by research grant from Catholic University of Daegu, Korea in 2004.

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AB - In this report, we prepared some 3-(2′,3′-epoxypropoxy)xanthones and their epoxide ring opened halohydrin analogues, and evaluated their cytotoxicity and topoisomerase II inhibition activity using doxorubicin and etoposide as references, respectively. Another xanthone compound 9, 1,3-di(2′,3′-epoxypropoxy)xanthone, was also synthesized and its DNA cross-linking property including other two biological activities investigated. The biological test results showed compound 9 possessed excellent cytotoxic and topoisomerase II inhibitory activity than other compounds tested. It also exhibited significant DNA cross-linking activities.

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KW - DNA cross-linking

KW - Topoisomerase II inhibition

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Synthesis of new xanthone analogues and their biological activity test-Cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study

Abstract

Bibliographical note

Keywords

UN SDGs

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