Synthesis of new xanthone analogues and their biological activity test-Cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study

Sangwook Woo, Ji Jung, Chongsoon Lee, Youngjoo Kwon, Younghwa Na

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

In this report, we prepared some 3-(2′,3′-epoxypropoxy)xanthones and their epoxide ring opened halohydrin analogues, and evaluated their cytotoxicity and topoisomerase II inhibition activity using doxorubicin and etoposide as references, respectively. Another xanthone compound 9, 1,3-di(2′,3′-epoxypropoxy)xanthone, was also synthesized and its DNA cross-linking property including other two biological activities investigated. The biological test results showed compound 9 possessed excellent cytotoxic and topoisomerase II inhibitory activity than other compounds tested. It also exhibited significant DNA cross-linking activities.

Original languageEnglish
Pages (from-to)1163-1166
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number5
DOIs
StatePublished - 1 Mar 2007

Keywords

  • Anti-cancer agents
  • DNA cross-linking
  • Topoisomerase II inhibition
  • Xanthones

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