Synthesis of ketones via organolithium addition to acid chlorides using continuous flow chemistry

Soo Yeon Moon; Seo Hee Jung; U. Bin Kim; Won Suk Kim

doi:10.1039/c5ra14890a

Synthesis of ketones via organolithium addition to acid chlorides using continuous flow chemistry

Soo Yeon Moon, Seo Hee Jung, U. Bin Kim, Won Suk Kim

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

An efficient method for the synthesis of ketones using organolithium and acid chlorides under continuous flow conditions has been developed. In contrast to standard batch chemistry, over-addition of the organolithium to the ketone for the formation of the undesired tertiary alcohol has been minimised representing a direct approach toward ketones.

Original language	English
Pages (from-to)	79385-79390
Number of pages	6
Journal	RSC Advances
Volume	5
Issue number	97
DOIs	https://doi.org/10.1039/c5ra14890a
State	Published - 14 Sep 2015

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© The Royal Society of Chemistry 2015.

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title = "Synthesis of ketones via organolithium addition to acid chlorides using continuous flow chemistry",

abstract = "An efficient method for the synthesis of ketones using organolithium and acid chlorides under continuous flow conditions has been developed. In contrast to standard batch chemistry, over-addition of the organolithium to the ketone for the formation of the undesired tertiary alcohol has been minimised representing a direct approach toward ketones.",

author = "Moon, \{Soo Yeon\} and Jung, \{Seo Hee\} and \{Bin Kim\}, U. and Kim, \{Won Suk\}",

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doi = "10.1039/c5ra14890a",

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AU - Moon, Soo Yeon

AU - Jung, Seo Hee

AU - Bin Kim, U.

AU - Kim, Won Suk

PY - 2015/9/14

Y1 - 2015/9/14

N2 - An efficient method for the synthesis of ketones using organolithium and acid chlorides under continuous flow conditions has been developed. In contrast to standard batch chemistry, over-addition of the organolithium to the ketone for the formation of the undesired tertiary alcohol has been minimised representing a direct approach toward ketones.

AB - An efficient method for the synthesis of ketones using organolithium and acid chlorides under continuous flow conditions has been developed. In contrast to standard batch chemistry, over-addition of the organolithium to the ketone for the formation of the undesired tertiary alcohol has been minimised representing a direct approach toward ketones.

UR - https://www.scopus.com/pages/publications/84942465899

U2 - 10.1039/c5ra14890a

DO - 10.1039/c5ra14890a

M3 - Article

AN - SCOPUS:84942465899

SN - 2046-2069

VL - 5

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EP - 79390

JO - RSC Advances

JF - RSC Advances

IS - 97

ER -

Synthesis of ketones via organolithium addition to acid chlorides using continuous flow chemistry

Abstract

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