Synthesis of ketones via organolithium addition to acid chlorides using continuous flow chemistry

Soo Yeon Moon, Seo Hee Jung, U. Bin Kim, Won Suk Kim

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

An efficient method for the synthesis of ketones using organolithium and acid chlorides under continuous flow conditions has been developed. In contrast to standard batch chemistry, over-addition of the organolithium to the ketone for the formation of the undesired tertiary alcohol has been minimised representing a direct approach toward ketones.

Original languageEnglish
Pages (from-to)79385-79390
Number of pages6
JournalRSC Advances
Volume5
Issue number97
DOIs
StatePublished - 14 Sep 2015

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