Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors

Hee Kyung Rhee; So Yun Lim; Mi Ja Jung; Youngjoo Kwon; Myung Hwa Kim; Hea Young Park Choo

doi:10.1016/j.bmc.2009.09.014

Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors

Hee Kyung Rhee
, So Yun Lim
, Mi Ja Jung
, Youngjoo Kwon
, Myung Hwa Kim
, Hea Young Park Choo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The isoquinolinone-based tetracyclic compounds were designed and synthesized and their PARP-I inhibitory activity was evaluated. Most of synthesized compounds showed fairly good activity. Also the most active compound 6 showed its activity on potentiation of anticancer agents, temozolamide and etoposide, by 1.7 times, respectively.

Original language	English
Pages (from-to)	7537-7541
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry
Volume	17
Issue number	21
DOIs	https://doi.org/10.1016/j.bmc.2009.09.014
State	Published - 1 Nov 2009

Bibliographical note

Funding Information:
This investigation was supported by Jeil Pharmaceutical Co.

Keywords

Cytotoxic potentiation
Isoquinolinone
PARP-1

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10.1016/j.bmc.2009.09.014

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title = "Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors",

abstract = "The isoquinolinone-based tetracyclic compounds were designed and synthesized and their PARP-I inhibitory activity was evaluated. Most of synthesized compounds showed fairly good activity. Also the most active compound 6 showed its activity on potentiation of anticancer agents, temozolamide and etoposide, by 1.7 times, respectively.",

keywords = "Cytotoxic potentiation, Isoquinolinone, PARP-1",

author = "Rhee, \{Hee Kyung\} and Lim, \{So Yun\} and Jung, \{Mi Ja\} and Youngjoo Kwon and Kim, \{Myung Hwa\} and Choo, \{Hea Young Park\}",

note = "Funding Information: This investigation was supported by Jeil Pharmaceutical Co.",

year = "2009",

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doi = "10.1016/j.bmc.2009.09.014",

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T1 - Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors

AU - Rhee, Hee Kyung

AU - Lim, So Yun

AU - Jung, Mi Ja

AU - Kwon, Youngjoo

AU - Kim, Myung Hwa

AU - Choo, Hea Young Park

N1 - Funding Information: This investigation was supported by Jeil Pharmaceutical Co.

PY - 2009/11/1

Y1 - 2009/11/1

N2 - The isoquinolinone-based tetracyclic compounds were designed and synthesized and their PARP-I inhibitory activity was evaluated. Most of synthesized compounds showed fairly good activity. Also the most active compound 6 showed its activity on potentiation of anticancer agents, temozolamide and etoposide, by 1.7 times, respectively.

AB - The isoquinolinone-based tetracyclic compounds were designed and synthesized and their PARP-I inhibitory activity was evaluated. Most of synthesized compounds showed fairly good activity. Also the most active compound 6 showed its activity on potentiation of anticancer agents, temozolamide and etoposide, by 1.7 times, respectively.

KW - Cytotoxic potentiation

KW - Isoquinolinone

KW - PARP-1

UR - https://www.scopus.com/pages/publications/73949157710

U2 - 10.1016/j.bmc.2009.09.014

DO - 10.1016/j.bmc.2009.09.014

M3 - Article

C2 - 19800803

AN - SCOPUS:73949157710

SN - 0968-0896

VL - 17

SP - 7537

EP - 7541

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 21

ER -

Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors

Abstract

Bibliographical note

Keywords

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