Abstract
The isoquinolinone-based tetracyclic compounds were designed and synthesized and their PARP-I inhibitory activity was evaluated. Most of synthesized compounds showed fairly good activity. Also the most active compound 6 showed its activity on potentiation of anticancer agents, temozolamide and etoposide, by 1.7 times, respectively.
Original language | English |
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Pages (from-to) | 7537-7541 |
Number of pages | 5 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 17 |
Issue number | 21 |
DOIs | |
State | Published - 1 Nov 2009 |
Bibliographical note
Funding Information:This investigation was supported by Jeil Pharmaceutical Co.
Keywords
- Cytotoxic potentiation
- Isoquinolinone
- PARP-1