Synthesis of carbon‐14 labelled cis‐malonato [(4R,5R)‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane] platinum(II) (ski 2053R)

Dae‐Kee ‐K Kim; Youngseok Kim; Jonggill Rim; Ganghyeok Kim; Jongsik Gam; Sungkun Song; Kwanghee Yoo; Key H. Kim

doi:10.1002/jlcr.2580340208

Synthesis of carbon‐14 labelled cis‐malonato [(4R,5R)‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane] platinum(II) (ski 2053R)

Dae‐Kee ‐K Kim
, Youngseok Kim
, Jonggill Rim
, Ganghyeok Kim
, Jongsik Gam
, Sungkun Song
, Kwanghee Yoo
, Key H. Kim

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The synthesis of ¹⁴C‐labelled cis‐malonato[(4R,5R)‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane]platinum(II) from [1,4‐¹⁴C] D‐tartaric acid is described. The overall radiochemical yield of the product in a eight‐step sequence was 23.8% and radiochemical purity was 98.5%.

Original language	English
Pages (from-to)	157-164
Number of pages	8
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	34
Issue number	2
DOIs	https://doi.org/10.1002/jlcr.2580340208
State	Published - Feb 1994

Keywords

(amino[C]methyl)‐2‐isopropyl‐1,3‐dioxolane]platinum(II)
SKI 2053R[C]
anticancer agent
cis‐malonato[(4R,5R)‐4,5‐bis
radiosynthesis

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@article{17e3452c85824aa393afa1c747bcb9c5,

title = "Synthesis of carbon‐14 labelled cis‐malonato [(4R,5R)‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane] platinum(II) (ski 2053R)",

abstract = "The synthesis of 14C‐labelled cis‐malonato[(4R,5R)‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane]platinum(II) from [1,4‐14C] D‐tartaric acid is described. The overall radiochemical yield of the product in a eight‐step sequence was 23.8\% and radiochemical purity was 98.5\%.",

keywords = "(amino[C]methyl)‐2‐isopropyl‐1,3‐dioxolane]platinum(II), SKI 2053R[C], anticancer agent, cis‐malonato[(4R,5R)‐4,5‐bis, radiosynthesis",

author = "Kim, \{Dae‐Kee ‐K\} and Youngseok Kim and Jonggill Rim and Ganghyeok Kim and Jongsik Gam and Sungkun Song and Kwanghee Yoo and Kim, \{Key H.\}",

year = "1994",

month = feb,

doi = "10.1002/jlcr.2580340208",

language = "English",

volume = "34",

pages = "157--164",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "John Wiley and Sons Ltd",

number = "2",

}

TY - JOUR

T1 - Synthesis of carbon‐14 labelled cis‐malonato [(4R,5R)‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane] platinum(II) (ski 2053R)

AU - Kim, Dae‐Kee ‐K

AU - Kim, Youngseok

AU - Rim, Jonggill

AU - Kim, Ganghyeok

AU - Gam, Jongsik

AU - Song, Sungkun

AU - Yoo, Kwanghee

AU - Kim, Key H.

PY - 1994/2

Y1 - 1994/2

N2 - The synthesis of 14C‐labelled cis‐malonato[(4R,5R)‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane]platinum(II) from [1,4‐14C] D‐tartaric acid is described. The overall radiochemical yield of the product in a eight‐step sequence was 23.8% and radiochemical purity was 98.5%.

AB - The synthesis of 14C‐labelled cis‐malonato[(4R,5R)‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane]platinum(II) from [1,4‐14C] D‐tartaric acid is described. The overall radiochemical yield of the product in a eight‐step sequence was 23.8% and radiochemical purity was 98.5%.

KW - (amino[C]methyl)‐2‐isopropyl‐1,3‐dioxolane]platinum(II)

KW - SKI 2053R[C]

KW - anticancer agent

KW - cis‐malonato[(4R,5R)‐4,5‐bis

KW - radiosynthesis

UR - https://www.scopus.com/pages/publications/0027979658

U2 - 10.1002/jlcr.2580340208

DO - 10.1002/jlcr.2580340208

M3 - Article

AN - SCOPUS:0027979658

SN - 0362-4803

VL - 34

SP - 157

EP - 164

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 2

ER -

Synthesis of carbon‐14 labelled cis‐malonato [(4R,5R)‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane] platinum(II) (ski 2053R)

Abstract

Keywords

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